vestichИзвестия Национальной академии наук Беларуси. Серия химических наукProceedings of the National Academy of Sciences of Belarus, Chemical Series1561-83312524-2342The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"vestich-155Research ArticleБИООРГАНИЧЕСКАЯ ХИМИЯBIOORGANIC CHEMISTRYПептидные аналоги эпитопов взаимодействия протеина А с иммуноглобулинами класса G, их синтез и исследование целевых свойствPeptide analogues of the epitopes of protein A interaction with IgG antibodies, their synthesis and investigation of target propertiesЛапкоА. В.LapkoA. V.gormoshkina@gmail.comКислаяД. Н.KislayaD. N.kislaja-dashka@rambler.ruГолубовичВ. П.GolubovichV. P.golubovich@iboch.bas-net.byИнститут биоорганической химии НАН БеларусиБеларусьThe Institute of Bioorganic Chemistry of the National Academy of Sciences of BelarusBelarus201508062016045661Copyright © Лапко А.В., Кислая Д.Н., Голубович В.П., 20162016Лапко А.В., Кислая Д.Н., Голубович В.П.Lapko A.V., Kislaya D.N., Golubovich V.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestichem.belnauka.by/jour/article/view/155

С помощью методов теоретического конформационного анализа отобрана структура и осуществлен синтез тетра-пептида формулы Phe-Gln-Phe-Tyr-OMe, аминокислотные остатки которого входят в состав активного центра протеина А, обеспечивающего его связывание с Fc-фрагментом иммуноглобулинов класса G. Активность данного тетрапеп-тида подтверждена исследованиями аффинности связывания с Fc-фрагментом иммуноглобулинов класса G.

Using methods of theoretical conformational analysis, the Phe-Gln-Phe-Tyr-OMe tetrapeptide has been designed and synthesized. Amino acid fragments of this tetrapeptide are present in the active center of protein A, providing its binding with the Fc-fragment of human IgG antibodies. Activity of this tetrapeptide has been confirmed by studies of its binding affinity with Fc-fragment of human IgG antibodies.

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The authors declare that there are no conflicts of interest present.