vestichИзвестия Национальной академии наук Беларуси. Серия химических наукProceedings of the National Academy of Sciences of Belarus, Chemical Series1561-83312524-2342The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"vestich-279Research ArticleОБЗОРЫПРИКЛАДНАЯ ЭНЗИМОЛОГИЯ ФОСФАТИДАЦИЛГИДРОЛАЗ В ИЗУЧЕНИИ ВЗАИМОСВЯЗИ «СТРУКТУРА – ФУНКЦИЯ» В РЯДУ БИОПОЛИМЕРОВ И НИЗКОМОЛЕКУЛЯРНЫХ БИОРЕГУЛЯТОРОВAPPLIED ENZYMOLOGY OF PHOSPHATIDACYLHYDROLASES IN A STUDY OF THE STRUCTURE–FUNCTION RELATIONSHIP IN THE SERIES OF BIOPOLYMERS AND LOW-MOLECULAR BIOREGULATORSЛитвинкоН. М.LitvinkoN. M.

д-р. хим. наук, доцент, зав. лаб.

D. Sc. (Chemistry), Associate Professor, Head of Laboratory

al_h@mail.ruИнститут биоорганической химии НАН БеларусиInstitute of Bioorganic Chemistry of the National Academy of Sciences of Belarus20170810201703115128Copyright © Литвинко Н.М., 20172017Литвинко Н.М.Litvinko N.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestichem.belnauka.by/jour/article/view/279

Представлен обзор основных экспериментальных результатов в области прикладной энзимологии фосфатидацилгидролаз при исследовании взаимосвязи «структура – функция» в процессе фосфолиполиза с участием растворимых (гемоглобин), периферических (цитохром b5), интегральных (CYP2В4) и якорных (CYP3А4) белков, а также низкомолекулярных биорегуляторов (хлор- и фосфорорганические соединения, производные 1,3-циклогек- сандиона, оксазола, тиотетроновых и жирных кислот). Обсуждены стратегические перспективы развития научных исследований и инновационных технологий в рамках биоорганической химии по направлению прикладная (инженерная) энзимология с участием фосфолиполитических ферментов.

 

Overview of the main experimental results in the field of applied enzymology of phosphatidacylhydrolases in a study of the structure – function relationship in the process of a phospholipolysis including soluble (hemoglobin), peripheral (b5), integral (CYP2B4) and anchor (CYP3A4) proteins, as well as low-molecular bioregulators (chlorine- and phosphoorganic compounds, derivatives of 1,3-cyclohexanedione, oxazole, the tiotetronic and fatty acids). The strategic prospects of development of scientific research and innovation within bioorganic chemistry at the field of applied (engineering) enzymology involving phospholipolytic enzymes, are discussed.

 

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The authors declare that there are no conflicts of interest present.