vestichИзвестия Национальной академии наук Беларуси. Серия химических наукProceedings of the National Academy of Sciences of Belarus, Chemical Series1561-83312524-2342The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1561-8331-2018-54-2-135-145vestich-314Research ArticleФИЗИЧЕСКАЯ ХИМИЯPHYSICAL CHEMISTRYВЛИЯНИЕ СТРУКТУРЫ СОПОЛИМЕРА И МУЛЬТИСЛОЙНОЙ ОБОЛОЧКИ НА АГРЕГАТИВНУЮ УСТОЙЧИВОСТЬ НАНОКАПСУЛ (ХИТОЗАН-прив-ПОЛИЭТИЛЕНГЛИКОЛЬ / ПОЛИСТИРОЛСУЛЬФОНАТ)nINFLUENCE OF COPOLYMER STRUCTURE AND LAYER-BY-LAYER SHELL ON AGGREGATIVE STABILITY OF (CHITOSAN-graft-POLYETHYLENE GLYCOL / POLYSTYRENE SULFONATE)n NANOCAPSULESШутоваТ. Г.ShutavaT. G.

Шутова Татьяна Геннадьевна – канд. хим. наук, вед. науч. сотрудник.

ул. Ф. Скорины, 36, 220141, Минск.

Tatsiana G. Shutava – Ph. D. (Сhemistry), Leading researcher. 

36, F. Skaryna Str., 220141, Minsk.

tshutova@yahoo.comЛивоновичК. С.LivanovichK. S.

Ливонович Константин Сергеевич – мл. науч. сотрудник.

ул. Ф. Скорины, 36, 220141, Минск.

Kanstantsin S. Livanovich – Junior researcher.

36, F. Skaryna Str., 220141, Minsk.

livonovich@yandex.byПаньковВ. В.PankovV. V.

Паньков Владимир Васильевич – д-р хим. наук, профессор, зав. кафедрой физической химии.

ул. Ленинградская, 14, 220030, Минск.

Vladimir V. Pankov – D. Sc. (Сhemistry), Professor, Head of the Department.

 

pankov@bsu.byИнститут химии новых материалов Национальной академии наук Беларуси.Institute of Chemistry of New Materials, National Academy of Sciences of Belarus.Белорусский государственный университет.Belarusian State University.201821062018542135145Copyright © Шутова Т.Г., Ливонович К.С., Паньков В.В., 20182018Шутова Т.Г., Ливонович К.С., Паньков В.В.Shutava T.G., Livanovich K.S., Pankov V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestichem.belnauka.by/jour/article/view/314

Нанокапсулы, состоящие из магнитного ядра и мультислойной полиэлектролитной оболочки на основе хитозана и его сополимеров с полиэтиленгликолем (ХН) и полистиролсульфоната (ПСС), получены методом послойной сборки. Изучено влияние числа бислоев ХН/ПСС в оболочке, степени полимеризации хитозана и наличия боковых цепей полиэтиленгликоля на агрегативно-седиментационную устойчивость нанокапсул в различных средах (воде, 0,9 %-ном растворе NaCl, эмбриональной телячьей сыворотке (ЭТС)). Показано, что диаметр нанокапсул (ХН/ПСС)n со слоем ПСС на поверхности в ЭТС не изменяется при 37 °С в течение 6–8 ч. Адсорбция альбумина на поверхности нанокапсул позволяет стабилизировать их в изотоническом 0,9 %-ном растворе NaCl и ЭТС. Совместное использование сополимера и альбумина в составе оболочек в целом улучшает агрегативно-седиментационную устойчивость нанокапсул в воде и позволяет получить устойчивые нанокапсулы с магнитным ядром за меньшее число циклов адсорбции.

Nanocapsules consisted of magnetic core and polyelectrolyte shell on the basis of chitosan or its polyethylene glycol (PEG) grafted copolymers (CH) and polystyrene sulfonate (PSS) were obtained by layer-by-layer assembly. The influence of the number of CH/PSS bilayers in a shell, polymerization degree of CH, and the presence of grafted PEG chains on aggregative and sedimentation stability of the obtained nanocapsules in different media (water, 0.9 % NaCl solution, fetal bovine serum (FBS)) was discussed. It was shown that the diameter of PSS-terminated (CH/PSS)n nanocapsules in FBS does not change at 37 °С for 6–8 h. Adsorption of bovine serum albumin on the surface of the layer-by-layer nanocapsules stabilizes them in isotonic 0.9 % solution of NaCl and FBS. Co-introduction of copolymer and albumin in the shells improves generally the aggregative stability of nanocapsules in water and allows one to obtain stable nanocapsules with magnetic core for fewer adsorption cycles.

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The authors declare that there are no conflicts of interest present.