vestichИзвестия Национальной академии наук Беларуси. Серия химических наукProceedings of the National Academy of Sciences of Belarus, Chemical Series1561-83312524-2342The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1561-8331-2018-54-3-305-313vestich-337Research ArticleОРГАНИЧЕСКАЯ ХИМИЯORGANIC CHEMISTRYСИНТЕЗ НОВЫХ 6-N-ЗАМЕЩЕННЫХ ПУРИНОВЫХ НУКЛЕОЗИДОВSYNTHESIS OF NEW 6-N-SUBSTITUTED PURINE NUCLEOSIDESКулакТ. И.KulakT. I.

Кулак Тамара Ивановна – канд. хим. наук, вед. науч. сотрудник

ул. акад. В.Ф. Купревича, 5/2, 220141, Минск

Tamara I. Kulak – Ph. D. (Chemistry), Leading Researcher

5/2, Acad. V.F. Kuprevich Str., 220141, Minsk

kulak@iboch.bas-net.byЯнковскаяД. В.YankovskayaD. V.

Янковская Дарья Владимировна – инженер-химик, НПЦ «ХимФармСинтез»

ул. акад. В.Ф. Купревича, 5/2, 220141, Минск

Darya V. Yankovskaya – Engineer-Chemist, Research and Experimental Production “ChemPharmSynthesis”

5/2, Acad. V.F. Kuprevich Str., 220141, Minsk

dasha-jankovskaja@yandex.byКонопличА. В.KonoplichA. V.

Коноплич Алена Викторовна – химик-фармацевт, НПЦ «ХимФармСинтез»

ул. акад. В.Ф. Купревича, 5/2, 220141, Минск

Alena V. Konoplich – Chemist-Pharmacist, Research and Experimental Production “ChemPharmSynthesis”

5/2, Acad. V.F. Kuprevich Str., 220141, Minsk

alena.konoplich96@gmail.comБуравскаяТ. Н.BuravskayaT. N.

Буравская Татьяна Николаевна – канд. хим. наук, ст. науч. сотрудник

ул. акад. В.Ф. Купревича, 5/2, 220141, Минск

Tatyana N. Buravskaya – Ph. D. (Chemistry), Senior Researcher, Research and Experimental Production “ChemPharmSynthesis”

5/2, Acad. V.F. Kuprevich Str., 220141, Minsk

butani@tut.byКалиниченкоЕ. Н.KalinichenkoE. N.

Калиниченко Елена Николаевна – член-корр., д-р хим наук, зам. директора

ул. акад. В.Ф. Купревича, 5/2, 220141, Минск

Elena N. Kalinichenko – Corresponding Member, D. Sc. (Chemistry), Deputy Director

5/2, Acad. V.F. Kuprevich Str., 220141, Minsk

kalinichenko@iboch.bas-net.byИнститут биоорганической химии Национальной академии наук БеларусиInstitute of Bioorganic Chemistry of the National Academy of Sciences of BelarusИнститут биоорганической химии Национальной академии наук Беларуси, НПЦ «ХимФармСинтез»Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus201814092018543305313Copyright © Кулак Т.И., Янковская Д.В., Коноплич А.В., Буравская Т.Н., Калиниченко Е.Н., 20182018Кулак Т.И., Янковская Д.В., Коноплич А.В., Буравская Т.Н., Калиниченко Е.Н.Kulak T.I., Yankovskaya D.V., Konoplich A.V., Buravskaya T.N., Kalinichenko E.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestichem.belnauka.by/jour/article/view/337

Осуществлен синтез новых производных пуриновых нуклеозидов, содержащих в 6-положении гетерооснования остатки N,N-диэтилэтилендиамина или N-(2-аминоэтил)пирролидина. Разработанные условия проведения реакции аминирования ряда 6-Cl-производных О-ацетилированных пуриновых нуклеозидов и сопутствующих реакций дезацилирования ОН-групп углеводного фрагмента под действием N-этилдиизопропиламина или N-(2-аминоэтил)пирролидина позволили получить деблокированные 6-N-замещенные нуклеозиды в одну стадию с хорошими выходами.

New derivatives of purine nucleosides containing the residues of N,N-diethylethylenediamine or N-(2-aminoethyl)pyrrolidine in 6-position of heterobase have been synthesized. The one-step preparation of 6-N-substituted nucleosides was performed in good yields by the amination of 6-Cl-derivatives of O-acetylated purine nucleosides and concomitant deacylation of OH-groups of a carbohydrate moiety with N,N-diethylethylenediamine or N-(2-aminoethyl)pyrrolidine.

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The authors declare that there are no conflicts of interest present.