vestichИзвестия Национальной академии наук Беларуси. Серия химических наукProceedings of the National Academy of Sciences of Belarus, Chemical Series1561-83312524-2342The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1561-8331-2019-55-4-391-399vestich-418Research ArticleНЕОРГАНИЧЕСКАЯ ХИМИЯINORGANIC CHEMISTRYЖидкофазный синтез карбонат-гидроксиапатитаWet synthesis of carbonated hydroxyapatiteГлазовИ. Е.GlazovI. E.

Глазов Илья Евгеньевич – младший научный сотрудник. 

ул. Сурганова, 9/1, 220072, Минск

Ilya E. Glazov – Junior Researcher. 

9/1, Surganova Str., 220072, Minsk

che.glazov@mail.ruКрутькоВ. К.Krut’koV. K.

Крутько Валентина Константиновна – кандидат химических наук, доцент, зав. лабораторией.

ул. Сурганова, 9/1, 220072, Минск

Valentina K. Krut’ko – Ph. D. (Chemistry), Associate Professor, Head of the Laboratory.

9/1, Surganova Str., 220072, Minsk

tsuber@igic.bas-net.byМусскаяО. Н.MusskayaO. N.

Мусская Ольга Николаевна – кандидат химических наук, доцент, старший научный сотрудник. 

ул. Сурганова, 9/1, 220072, Минск

Olga N. Musskaya – Ph. D. (Chemistry), Associate Professor, Senior Researcher.

9/1, Surganova Str., 220072, Minsk

musskaja@igic.bas-net.byКулакА. И.KulakA. I.

Кулак Анатолий Иосифович – член-корреспондент, доктор химических наук, профессор, директор.

ул. Сурганова, 9/1, 220072, Минск

Anatoly I. Kulak – Corresponding Member, D. Sc. (Chemistry), Professor, Director.

9/1, Surganova Str., 220072, Minsk

 

kulak@igic.bas-net.byИнститут общей и неорганической химии Национальной академии наук БеларусиInstitute of General and Inorganic Chemistry of the National Academy of Sciences of Belarus201906122019554391399Copyright © Глазов И.Е., Крутько В.К., Мусская О.Н., Кулак А.И., 20192019Глазов И.Е., Крутько В.К., Мусская О.Н., Кулак А.И.Glazov I.E., Krut’ko V.K., Musskaya O.N., Kulak A.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestichem.belnauka.by/jour/article/view/418

Методом жидкофазного синтеза получен карбонат-гидроксиапатит с преимущественным Б-типом замещения при варьировании температуры, концентрации карбонат-ионов в реакционной смеси и времени выдерживания под маточным раствором. Карбонат-гидроксиапатит, синтезированный при 80 °C, содержит наибольшее количество (до 9 мас.%) примеси кальцита и обладает невысокой удельной поверхностью (40 м2/г). Понижение температуры синтеза до 20 °C приводит к незначительному уменьшению содержания примеси кальцита (5–7 мас.%) и увеличению удельной поверхности до 125 м2/г. Введение стадии созревания осажденного при 20 °C карбонат-гидроксиапатита длительностью 4 сут способствует подавлению образования примеси кальцита и увеличению удельной поверхности до 155 м2/г.

Carbonated hydroxyapatite of predominant B-type of substitution has been synthesized at various temperatures, carbonate concentrations and time of immersion in mother solution. Carbonated hydroxyapatite synthesized at 80 °C contains the largest amount (up to 9 wt.%) of calcite impurity and has a low specific surface area (40 m2/g). Lowering the synthesis temperature to 20 °C leads to a slight decrease in the content of calcite impurity (up to 5–7 wt.%) and an increase in the specific surface up to 125 m2/g. The introduction of the maturation stage for carbonated hydroxyapatite precipitated at 20 °C for 4 days suppresses the calcite impurity formation and leads to the increase in the specific surface up to 155 m2/g.

carbonated hydroxyapatitewet synthesiscalcitematurationB-type of substitutionReferencesBohner, M. Calcium phosphate bone graft substitutes: Failures and hopes / M. Bohner, L. Galea, N. Doebelin // J. Eur. Cer. Soc. – 2012. – Vol. 32, N 11. – P. 2663–2671. htps://doi.org/10.1016/j.jeurceramsoc.2012.02.028Bohner M., Galea L., Doebelin N. Calcium phosphate bone graft substitutes: Failures and hopes. Journal of the European Ceramic Society 2012, vol. 32, no. 11, pp. 2663–2671. https://doi.org/10.1016/j.jeurceramsoc.2012.02.028Synthesis, identification and determination of impurities in bioactive hydroxyapatite / V. K. Tsuber [et al.] // Pharmaceutical Chemistry J. – 2006. – Vol. 40, N 80. – P. 455–458. https://doi.org/10.1007/s11094-006-0151-23.Tsuber V. K., Lesnikovich L. A., Kulak A. I., Trofimova I. V., Petrov P. T., Trukhacheva T. V., Kovalenko Yu. D., Krasil’nikova V. L. Synthesis, identification and determination of impurities in bioactive hydroxyapatite. Pharmaceutical Chemistry Journal, 2006, vol. 40, no. 80, pp. 455–458. https://doi.org/10.1007/s11094-006-0151-2Preparation of Bioactive Mesoporous Calcium Phosphate Granules / O. N. Musskaya [et al.] // Inorganic Materials. – 2018. – Vol. 54, N 2. – P. 117–124. https://doi.org/10.1134/S0020168518020115Musskaya O. N., Kulak A. I., Krut’ko V. K., Lesnikovich Yu. A., Kazbanov V. V., Zhitkova N. S. Preparation of Bioactive Mesoporous Calcium Phosphate Granules. Inorganic Materials, 2018, vol. 54, no. 2, pp. 117–124. https://doi.org/10.1134/S0020168518020115Адсорбционно-структурные свойства ксерогелей фосфатов кальция, полученных жидкофазным синтезом / О. Н. Мусская [и др.] // Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов. – 2018. – Т. 10. – С. 468–477.Musskaya O. N., Kulak A. I., Krut’ko V. K., Glazov I. E. Adsorption-structural properties of calcium phosphates xerogels obtained by liquid-phase synthesis. Fiziko-himicheskie aspekty izucheniya klasterov, nanostruktur i nanomaterialov = Physical chemical aspects of clusters, nanostructures and nanomaterials study, 2018, vol. 10, pp. 468–477 (in Russian).Biodegradable polymer matrix nanocomposites for tissue engineering: a review / I. Armentano [et al.] // Polymer degradation and stability. – 2010. – Vol. 95, N 11. – P. 2126–2146. https://doi.org/10.1016/j.polymdegradstab.2010.06.007Armentano I., Dottori M., Fortunati E., Mattioli S., Kenny J. M. Biodegradable polymer matrix nanocomposites for tissue engineering: a review. Polymer degradation and stability, 2010, vol. 95, no. 11, pp. 2126–2146. https://doi.org/10.1016/j.polymdegradstab.2010.06.007Biphasic calcium phosphate bioceramics: preparation, properties and applications / R. Z. LeGeros [et al.] // J. Mater. Sci.: Mater. Med. – 2003. – Vol. 14, N 3. – P. 201–209. https://doi.org/10.1023/A:1022872421333LeGeros R. Z., Lin S., Rohanizadeh R., Mijare D., LeGeros J. P. Biphasic calcium phosphate bioceramics: preparation, properties and applications. Journal of materials science: materials in medicine, 2003, vol. 14, no. 3, pp. 201–209. https://doi.org/10.1023/A:1022872421333Lafon, J. P. Processing of AB-type carbonated hydroxyapatite Ca10−x(PO4)6−x(CO3)x(OH)2−x−2y(CO3)y ceramics with controlled composition / J. P. Lafon, E. Champion, D. Bernache-Assollant // J. Eur. Cer. Soc. – 2008. – Vol. 28, N 1. – P. 139–147. https://doi.org/10.1016/j.jeurceramsoc.2007.06.009Lafon J. P., Champion E., Bernache-Assollant D. Processing of AB-type carbonated hydroxyapatite Ca10−x(PO4)6−x(CO3)x (OH)2−x−2y(CO3)y ceramics with controlled composition. Journal of the European Ceramic Society, 2008, vol. 28, no. 1, pp. 139–147. https://doi.org/10.1016/j.jeurceramsoc.2007.06.009White, A. A. Hydroxyapatite–carbon nanotube composites for biomedical applications: a review / A. A. White, S. M. Best, I. A. Kinloch // Int. J. App. Cer. Tech. – 2007. – Vol. 4, N 1. – P. 1–13. https://doi.org/10.1111/j.1744-7402.2007.02113.xWhite A. A., Best S. M., Kinloch I. A. Hydroxyapatite-carbon nanotube composites for biomedical applications: a review. International Journal of Applied Ceramic Technology, 2007, vol. 4, no. 1, pp. 1–13. https://doi.org/10.1111/j.1744-7402.2007.02113.xKrut’ko, V. K. Thermal Transformations of Composites Based on Hydroxyapatite and Zirconia / V. K. Krut’ko, A. I. Kulak, O. N. Musskaya // Inorganic Materials. – 2017. – Vol. 53, N 4. – P. 429–436. https://doi.org/10.1134/S0020168517040094Krut’ko V. K., Kulak A. I., Musskaya O. N. Thermal Transformations of Composites Based on Hydroxyapatite and Zirconia. Inorganic Materials, 2017, vol. 53, no. 4, pp. 429–436. https://doi.org/10.1134/S0020168517040094Пленочные композиты на основе гидроксиапатита и поливинилового спирта / О. Н. Мусская [и др.] // Полимерные материалы и технологии. – 2017. – Т. 3, № 2. – С. 28–33. https://doi.org/10.32864/polymmattech-2017-3-2-28-33Musskaya, O. N., Krut’ko V. K., Kulak A. I., Lesnikovich Yu. A. Сomposite films based on polyvinyl alcohol and hydroxyapatite. Polymer materials and technologies, 2017, vol. 3, no. 2, pp. 28–33 (in Russian). https://doi.org/10.32864/polymmattech-2017-3-2-28-33Синтез композиционных материалов на основе фосфатов кальция и компонентов крови / И. Е. Глазов [и др.] // Вес. Нац. акад. навук Беларусi. Сер. хiм. навук. – 2019. – Т. 55, № 2. – С. 135–141. https://doi.org/10.29235/1561-8331-201955-2-135-141Glazov I. E., Vlasov R. A., Krut’ko V. K., Musskaya O. N. Synthesis of composite materials based on calcium phosphates and blood components. Vestsi Natsyyanal’nai akademii navuk Belarusi. Seryya khimichnykh navuk = Proceedings of the National Academy of Sciences of Belarus. Chemical series, 2019, vol. 55, no. 2, pp. 135–141 (in Russian). https://doi.org/10.29235/1561-8331-2019-55-2-135-141Aoki, H. Outline of hydroxyapatite / H. Aoki // Science and Medical Applications of Hydroxyapatite. – Tokyo: JAAS, 1991. – P. 1–10.Aoki H. Outline of hydroxyapatite. Science and Medical Applications of Hydroxyapatite. Tokyo: JAAS, 1991, pp. 1–10.Корреляционные зависимости между фазовым, элементным и аминокислотным составом физиогенных, патогенных ОМА и их синтетических аналогов / О. А. Голованова [и др.] // Системы. Методы. Технологии. – 2012. – № 4. – С. 131–139.Golovanova O. A., Gerk S. A., Kuriganova A. N., Izmaylov R. R. Correlation dependences between phase, elemental and amino acid composition of physiogenic and pathogenic OMA and their synthetic analogues. Sistemy. Metody. Tehnologii = Systems. Methods. Technologies, 2012, no. 4, pp. 131–139 (in Russian).Osteoblast and osteoclast responses to A/B type carbonate-substituted hydroxyapatite ceramics for bone regeneration /M.M. Germaini [et al.] // Biomedical Materials. – 2017. – Vol. 12, N 3. – P. 035008. https://doi.org/10.1088/1748-605X/aa69c3/metaGermaini M. M., Detsch R., Grünewald A., Magnaudeix A., Lalloue F., Boccaccini A. R., Champion E. Osteoblast and osteoclast responses to A/B type carbonate-substituted hydroxyapatite ceramics for bone regeneration. Biomedical Materials, 2017, vol. 12, no. 3, pp. 035008. https://doi.org/10.1088/1748-605X/aa69c3/metaNovel synthesis of AB-type carbonated hydroxyapatite hierarchical microstructures with sustained drug delivery properties / R. Sun [et al.] // CrystEngComm. – 2016. – Vol. 18, N 41. – P. 8030–8037. https://doi.org/10.1039/C6CE01494ASun R., Yang L., Zhang Y., Chu F., Wang G., Ly Yu., Chen K. Novel synthesis of AB-type carbonated hydroxyapatite hierarchical microstructures with sustained drug delivery properties. CrystEngComm, 2016, vol. 18, no. 41, pp. 8030–8037. https://doi.org/10.1039/C6CE01494AEffect of processing conditions on the crystallinity and structure of carbonated calcium hydroxyapatite (CHAp) / E. Garskaite [et al.] // CrystEngComm. – 2014. – Vol. 16, N 19. – P. 3950–3959. https://doi.org/10.1039/C4CE00119BGarskaite E., Gross K.-A., Yang S.-W., Yang T. Ch.-K., Yang J.-C., Kareira A. Effect of processing conditions on the crystallinity and structure of carbonated calcium hydroxyapatite (CHAp). CrystEngComm, 2014, vol. 16, no 19, pp. 3950–3959. https://doi.org/10.1039/C4CE00119BБиорезорбируемые порошковые материалы на основе Ca10–xNax(PO4)6–x(CO3)x(OH)2 / E. C. Ковалёва [и др.] // Ученые записки Казан. ун-та. Сер. Естественные науки. – 2010. – Т. 152, № 1. – С. 79–98.Kovaleva E. S., Shabanov M. P., Putlayev V. I., Filippov Ya. Yu., Tretyakov Y. D., Ivanov V. K Bioresorbable powder materials based on Ca10–xNax(PO4)6–x(CO3)x(OH)2. Uchonye zapisky Kazanskogo universiteta = Scientific notes of the Kazan University, 2010, vol. 152, no. 1. – pp. 79–98 (in Russian).Carbonate dhydroxyapatite as bone substitute / E. Landi [et al.] // J. Eur. Cer. Soc. – 2003. – Vol. 23, N 15. – P. 2931–2937. https://doi.org/10.1016/S0955-2219(03)00304-2Landi E., Celotti G., Logroscino G., Tampieri A. Carbonated hydroxyapatite as bone substitute. Journal of the European Ceramical Society, 2003, vol. 23, no. 15, pp. 2931–2937. https://doi.org/10.1016/S0955-2219(03)00304Gibson, I. R. Novel synthesis and characterization of an AB-type carbonate-substituted hydroxyapatite / I. R. Gibson, W. Bonfield // J. Biomed. Mater. Res. – 2002. – Vol. 59, N 4. – P. 697–708. https://doi.org/10.1002/jbm.10044Gibson I. R., Bonfield W. Novel synthesis and characterization of an AB-type carbonate-substituted hydroxyapatite. Journal of Biomedical Materials Research, 2002, vol. 59, no. 4, pp. 697–708. https://doi.org/10.1002/jbm.10044Characterization of the transformation from calcium-deficient apatite to β-tricalcium phosphate / I. R. Gibson [et al.] // J. Mater. Sci.: Mater. Med. – 2000. – Vol. 11, N 9. – P. 533–539. https://doi.org/10.1023/A:1008961816208Gibson I. R., Rehman I., Best S. M., Bonfield W. Characterization of the transformation from calcium-deficient apatite to β-tricalcium phosphate. Journal of materials science: materials in medicine, 2000, vol. 11, no. 9, pp. 533–539. https://doi.org/10.1023/A:100896181620821Wong, W. Y. Synthesis and sintering-wet carbonation of nano-sized carbonated hydroxyapatite / W. Y. Wong, A. F. M. Noor // Procedia Chemistry. – 2016. – Vol. 19. – P. 98–105. https://doi.org/10.1016/j.proche.2016.03.121Wong W. Y., Noor A. F. M. Synthesis and sintering-wet carbonation of nano-sized carbonated hydroxyapatite. Procedia Chemistry, 2016, vol. 19, pp. 98–105. https://doi.org/10.1016/j.proche.2016.03.121Witoon, T. Characterization of calcium oxide derived from waste eggshell and its application as CO2 sorbent // Ceram. Int. – 2011. – Vol. 37, N 8. – P. 3291–3298. https://doi.org/10.1016/j.ceramint.2011.05.125Witoon T. Characterization of calcium oxide derived from waste eggshell and its application as CO2 sorbent. Ceramics International, 2011, vol. 37, no. 8, pp. 3291–3298. https://doi.org/10.1016/j.ceramint.2011.05.125

The authors declare that there are no conflicts of interest present.