vestichИзвестия Национальной академии наук Беларуси. Серия химических наукProceedings of the National Academy of Sciences of Belarus, Chemical Series1561-83312524-2342The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1561-8331-2020-56-2-135-142vestich-576Research ArticleФИЗИЧЕСКАЯ ХИМИЯPHYSICAL CHEMISTRYПолучение и свойства магнитных микросфер на основе магнитита и гидрофильных полимеровSynthesis and properties of magnetic microspheres based on magnetite and hydrophilic polymersЛазневК. В.LaznevK. V.

Лазнев Константин Владимирович – науч. сотрудник

ул. Ф. Скорины, 36, 220141, Минск

Konstantin V. Laznev – Researcher

36, F. Skaryna Str., 220141, Minsk

kvlaznev@mail.ruШумскаяЕ. Е.ShumskayaYe. Y.

Шумская Елена Евгеньевна – науч. сотрудник

ул. Ф. Скорины, 36, 220141, Минск

Yelena Y. Shumskaya – Researcher

36, F. Skaryna Str., 220141, Minsk

lunka7@mail.ruАгабековВ. Е.AgabekovV. Y.

Агабеков Владимир Енокович – академик, д-р хим. наук, профессор, директор 

ул. Ф. Скорины, 36, 220141, Минск

Vladimir Y. Agabekov – Academician, D. Sc. (Chemistry), Professor, Director 

36, F. Skaryna Str., 220141, Minsk

ichnm@ichnm.basnet.byИнститут химии новых материалов Национальной академии наук БеларусиInstitute of Chemistry of New Materials of the National Academy of Sciences of Belarus202006062020562135142Copyright © Лазнев К.В., Шумская Е.Е., Агабеков В.Е., 20202020Лазнев К.В., Шумская Е.Е., Агабеков В.Е.Laznev K.V., Shumskaya Y.Y., Agabekov V.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestichem.belnauka.by/jour/article/view/576

Эмульсионным методом из содержащих магнитные наночастицы растворов альгината, пектина, желатина, хитозана и поливинилового спирта получены магнитные микросферы (ММС) с индексом полидисперсности ≤ 0,1. Ковалентно сшитые глутаральдегидом желатиновые, хитозановые и поливинилспиртовые микросферы не гидролизуются в среде pH 7,4 при комнатной температуре и устойчивы к ультразвуку. Микросферы, содержащие суперпарамагнитные частицы магнетита, не проявляют остаточной намагниченности. На основе поливинилспиртовых и хитозановых ММС разработаны наборы для иммуномагнитной сепарации клеток и микроорганизмов.

Using emulsification technique, magnetic microspheres (MMS) were prepared from solutions of alginate, pectin, gelatin, chitosan and polyvinyl alcohol. Index of polidispersity of the microspheres was ≤ 0.1. The microspheres from gelatin, chitosan and polyvinyl alcohol covalently crosslinked with glutaraldehyde were resistant to sonication and hydrolysis at room temperature in buffer solution with pH   7.4. The microspheres containing superparamagnetic magnetite particles demonstrated no residual magnetization. After modification, chitosan and polyvinyl alcohol MMS were used for immunomagnetic separation of cells and germs.

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The authors declare that there are no conflicts of interest present.