vestichИзвестия Национальной академии наук Беларуси. Серия химических наукProceedings of the National Academy of Sciences of Belarus, Chemical Series1561-83312524-2342The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1561-8331-2020-56-2-38-166-180vestich-580Research ArticleОРГАНИЧЕСКАЯ ХИМИЯORGANIC CHEMISTRYСинтез химерных амидов 2-ариламинопиримидинового рядаSynthesis of chimeric amides of 2-arilaminopyrimidine seriesИгнатовичЖ. В.IgnatovichZh. V.

Игнатович Жанна Владимировна – канд. хим. наук, зав. лаб. 

ул. Ф. Скорины, 36, 220141, Минск

Zhanna V. Ignatovich – Ph. D. (Chemistry), Head of the Laboratory

36, F. Skorina Str., 220141, Minsk

ignatovich@ichnm.basnet.byИнститут химии новых материалов Национальной академии наук БеларусиInstitute of Chemistry of New Materials of the National Academy of Sciences of Belarus202006062020562166180Copyright © Игнатович Ж.В., 20202020Игнатович Ж.В.Ignatovich Z.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestichem.belnauka.by/jour/article/view/580

Рассмотрены методические подходы к синтезу 2-арил-аминопиримидиновых амидов с прогнозируемой противоопухолевой активностью с использованием конструирования химерных молекул путем комбинирования фармакофорных фрагментов известных противоопухолевых лекарственных препаратов. Представлены результаты по синтезу химерных амидов, в которых наряду с 2-аминопиримидиновым фрагментом имеются фрагменты других азот- и кислородсодержащих гетероциклов (пиперазина, морфолина, изоксазола и др.), ароматических циклов (бензола, метилнитроанилина, фенилендиамина) и функциональные (метил-, амино-, карбокси- и др.) группы в различных положениях молекулы.

Methodological approaches to the synthesis of 2-arylpyrimidine amides with predicted antitumor activity using the design of chimeric molecules by combining pharmacophore fragments of known antitumor drugs are considered. The results of the synthesis of chimeric amides containing, along with the 2-amino-pyrimidine fragment, fragments of other nitrogen and oxygen-containing heterocycles (piperazine, morpholine, isoxazole, etc.), aromatic cycles (benzene, methylnitroaniline, phenylenediamine) and functional (methyl-, amino-, carboxy-, etc.) groups in different positions of the molecule, are presented.

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The authors declare that there are no conflicts of interest present.