vestichИзвестия Национальной академии наук Беларуси. Серия химических наукProceedings of the National Academy of Sciences of Belarus, Chemical Series1561-83312524-2342The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1561-8331-2020-56-3-3U-317vestich-599Research ArticleОРГАНИЧЕСКАЯ ХИМИЯORGANIC CHEMISTRYСинтез лейцинсодержащих циклодипептидовSynthesis of leucine-based cyclic dipeptidesГайдукевичВ. А.HaidukevichV. A.

Гайдукевич Вероника Александровна - научный сотрудник.

Ул. Сурганова, 13, 220072, Минск

Veranika A. Haidukevich - Researcher.

13, Surganov Str., 220072, Minsk

veronika_haid-ukevich@mail.ruПоповаЛ. А.PopovaL. A.

Попова Людмила Александровна - старший научный сотрудник.

Ludmila A. Popova - Senior Researcher.

13, Surganov Str., 220072, Minsk

КурманП. В.KurmanP. V.

Курман Петр Владимирович - кандидат химических наук, ведущий научный сотрудник.

Ул. Акад. В. Ф. Куп-ревича, 5/2, 220141, Минск

Peter V. Kurman - Ph. D. (Chemistry), Leading Researcher.

5/2, Academician V. F. Kuprevich Str., 220141, Minsk

peter_kurman@tut.byКнижниковВ. А.KnizhnikovV. A.

Книжников Валерий Алексеевич - доктор химических наук, заведующий лабораторией.

Ул. Сурганова, 13, 220072, Минск

Valeriy A. Knizhnikov - D. Sc. (Chemistry), Head of the Laboratory.

13, Surganov Str., 220072, Minsk

knizh@ifoch.bas-net.byИнститут физико-органической химии, Национальная академия наук БеларусиInstitute of Physical Organic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus,Институт биоорганической химии, Национальная академия наук БеларусиInstitute of Bioorganic Chemistry, National Academy of Sciences of Belarus202028082020563311317Copyright © Гайдукевич В.А., Попова Л.А., Курман П.В., Книжников В.А., 20202020Гайдукевич В.А., Попова Л.А., Курман П.В., Книжников В.А.Haidukevich V.A., Popova L.A., Kurman P.V., Knizhnikov V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestichem.belnauka.by/jour/article/view/599

3-бензил-6-изобутилпиперазин-2,5-дион [цикло(лейцилфенилаланил)], 3-изобутилпиперазин-2,5-дион [цикло(лейцилглицил)] и 3-(втор-бутил-)-6-изобутил-пиперазин-2,5-дион [цикло(лейцилизолейцин)] получены циклизацией метиловых эфиров трет-бутилоксикарбонильных производных дипептидов, для синтеза которых был использован как карбодиимидный метод образования пептидной связи, так и метод смешанных ангидридов.

3-benzyl-6-isobutylpiperazin-2,5-dione [cyclo(leucylphenylalanyl)], 3-isobutylpiperazin-2,5-dione [cyclo(-leucylglycyl)] and 3-(sec-butyl-)-6-isobutyl-piperazine-2,5-dione [cyclo(leucylisoleucine)] have been obtained by cyclization of methyl esters of tert-butyloxycarbonyl derivatives of dipeptides, for the synthesis of which both carbodiimide-promoted peptide bond formation and the mixed anhydride method were used.

25-дикетопиперазинысинтезцикло(Leu-Gly)цикло(Leu-Ile)цикло(Leu-Phe)трет-бутил-оксикарбонильная аминозащитная группакарбодиимидный методметод смешанных ангидридовлейцинсодержащие циклодипептиды25-diketopiperazinessynthesiscyclo(Leu-Gly)cyclo(Leu-lle)cyclo(Leu-Phe)tert-butyloxycarbonyl amino protecting groupcarbodiimide methodmixed anhydrides methodleucine-based cyclic dipeptidesReferencesPrasad, C. Bioactive cyclic dipeptides / C. Prasad // Peptides. - 1995. - Vol. 16, N 1. - P. 151-164. https://doi. org/10.1016/0196-9781(94)00017-ZPrasad C. Bioactive cyclic dipeptides. Peptides, 1995, vol. 16, no. 1, pp. 151-164. https://doi.org/10.1016/0196-9781(94)00017-Zde Carvalho, M. P. Antimicrobial and biofilm inhibiting diketopiperazines / M. P. de Carvalho, W. R. Abraham // Curr. Med. Chem. - 2012. - Vol. 19, N 21. - P. 3564-3577. https://doi.org/10.2174/092986712801323243de Carvalho M. P.Antimicrobial and biofilm inhibiting diketopiperazines. 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The authors declare that there are no conflicts of interest present.