vestichИзвестия Национальной академии наук Беларуси. Серия химических наукProceedings of the National Academy of Sciences of Belarus, Chemical Series1561-83312524-2342The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1561-8331-2021-57-1-41-47vestich-630Research ArticleОРГАНИЧЕСКАЯ ХИМИЯORGANIC CHEMISTRYПроизводные поли(этиленгликоля) в синтезе водорастворимого цианинового красителя Су5Peg derivatives for the synthesis of water-soluble cyanine dye Cy5СеверинчикТ. П.SeviarynchykT. P.

Северинчик Татьяна Петровна - младший научный сотрудник.ул. Сурганова, 13, 220072, Минск.

Tatsiana P. Seviarynchyk - Junior Researcher. Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus.13, Surganov Str., 220072, Minsk.

tanyaseverinchik@gmail.comЦавловскийД. В.TsaulouskiDz. V.

Цавловский Дмитрий Валентинович - научный сотрудник.ул. Сурганова, 13, 220072, Минск.

Dzmitry V. Tsaulouski - Researcher. Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus.13, Surganov Str., 220072, Minsk.

tsaulouski@gmail.comШаркоО. Л.SharkoO. L.

Шарко Ольга Леонидовна - кандидат химических наук, ведущий научный сотрудник.ул. Сурганова, 13, 220072, Минск.

Olga L. Sharko - Leading Researcher. Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus.13, Surganov Str., 220072, Minsk.

olsharko@gmail.comШманайВ. В.ShmanaiV. V.

Шманай Вадим Владимирович - кандидат химических наук, заведующий лабораторией.ул. Сурганова, 13, 220072, Минск.

Vadim V. Shmanai - Ph. D. (Chemistry), Head of the Laboratory. Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus.13, Surganov Str., 220072, Minsk.

shmanai@ifoch.bas-net.byИнститут физико-органической химии Национальной академии наук БеларусиБеларусьInstitute of Physical Organic Chemistry of the National Academy of Sciences of BelarusBelarus2021090220215714147Copyright © Северинчик Т.П., Цавловский Д.В., Шарко О.Л., Шманай В.В., 20212021Северинчик Т.П., Цавловский Д.В., Шарко О.Л., Шманай В.В.Seviarynchyk T.P., Tsaulouski D.V., Sharko O.L., Shmanai V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestichem.belnauka.by/jour/article/view/630

Предложен эффективный метод получения водорастворимого цианинового красителя Су5 при помощи жидкофазного синтеза на водорастворимых полимерных носителях (ЖСВП). В качестве полимерной подложки использовали метиловый эфир поли(этиленгликоля) с молекулярной массой 2000, что позволило упростить процесс характеризации продуктов на промежуточных стадиях синтеза ЯМР-спектроскопией. Данный подход позволяет легко получить необходимые цианиновые красители, которые широко используются в качестве флуоресцентных меток и являются востребованными модифицирующими реагентами в биохимии и медицине.

An effective method for the preparation of water-soluble cyanine dye Cy5 using the soluble polymers supported liquid-phase organic synthesis (LPOS) was proposed. Poly (ethylene glycol) methyl ether with a molecular weight of 2000 was used as a polymer substrate, which allowed us to simplify the characterization of products at intermediate stages of synthesis by NMR spectroscopy. This approach makes it easy to obtain the necessary cyanine dyes, which are widely used as fluorescent labels and are popular modifying reagents in biochemistry and medicine.

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The authors declare that there are no conflicts of interest present.