vestichИзвестия Национальной академии наук Беларуси. Серия химических наукProceedings of the National Academy of Sciences of Belarus, Chemical Series1561-83312524-2342The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1561-8331-2021-57-1-70-86vestich-633Research ArticleБИООРГАНИЧЕСКАЯ ХИМИЯBIOORGANIC CHEMISTRYДействие ультрафиолетового излучения на тиамин и дисульфиды тиаминаEffect of ultraviolet on thiamine and thiamine disulfidesАгейкоС. А.AheikaS. A.

Агейко Светлана Алексеевна - научный сотрудник.БЛК, 50, 230030, Гродно.

Svetlana A. Aheika – Researcher, Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus.BLK, 50, 230030, Grodno.

swet.labor2010@yandex.byСтепуроВ. И.StsiapuraV. I.

Степуро Виталий Иванович - кандидат физико-математических наук, ведущий научный сотрудник, доцент.ул. Ожешко, 22, 230023, Гродно.

Vitali I. Stsiapura - Ph. D. (Physics and Mathematics), Leading Researcher, Associate Professor, Yanka Kupala Grodno State University.22, Ozheshko Str., 230023, Grodno.

stsiapura@gmail.comСмирновВ. Ю.SmirnovV. Yu.

Смирнов Виталий Юрьевич - старший научный сотрудник, доцент.ул. Горького, 80, 230009, Гродно.

Vitaly Yu. Smirnov - Senior Researcher, Associate Professor, Grodno State Medical University.80, Gorky Str., 230009, Grodno.

vit_sm@mail.ruСтепуроИ. И.StepuroI. I.

Степуро Иван Иванович - кандидат биологических наук, заведующий лабораторией, доцент.БЛК, 50, 230030, Гродно.

Ivan I. Stepuro - Ph. D. (Biology), Leading Researcher, Assistant Professor, Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus.BLK, 50, 230030, Grodno.

scepura@gmail.comИнститут биохимии биологически активных соединений Национальной академии наук БеларусиInstitute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of BelarusГродненский государственный университет им. Янки КупалыYanka Kupala State University of GrodnoГродненский государственный медицинский университетGrodno State Medical University2021090220215717086Copyright © Агейко С.А., Степуро В.И., Смирнов В.Ю., Степуро И.И., 20212021Агейко С.А., Степуро В.И., Смирнов В.Ю., Степуро И.И.Aheika S.A., Stsiapura V.I., Smirnov V.Y., Stepuro I.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestichem.belnauka.by/jour/article/view/633

Под действием ультрафиолетового солнечного излучения (а также ультрафиолетового излучения ртутной лампы с λ > 300 нм) на тиамин дисульфид в нейтральной водной среде образуются молекулы тиамина с закрытым тиазоловым циклом и молекулы тиазолона тиамина. Асимметричный дисульфид тиамина, например тиаминпропил дисульфид, под действием ультрафиолетового излучения (UVA диапазон) образует тиамин и пропилдисульфид соответственно. Тиамин и тиазолон тиамина устойчивы к действию излучения 320-400 нм (UVA диапазон). При воздействии ультрафиолетового излучения с λ от 200 до 300 нм происходит фотодеструкция тиамина и тиазолона тиамина и образуется 2-метил4-амино-5-аминометил-пиримидин в качестве основного продукта. Обсуждается возможность использования дисульфидных производных тиамина как перспективного класса антикатарактальных препаратов, а также препаратов для снижения токсического действия ультрафиолетового излучения на сетчатку глаза.

In a neutral medium, the exposure of thiamine disulfide to the ultraviolet of solar radiation (as well as to the ultraviolet radiation of mercury lamp with λ > 300 nm) results in the formation of a thiamine molecule with closed thiazole ring and a molecule of thiamine thiazolone. Asymmetric thiamine disulfides, e.g., thiamine propyl disulfide, on exposure to ultraviolet (UVA range) produced thiamine and propyl disulfides. Thiamine and thiazolone of thiamine are stable upon exposure to light of 320-400 nm (UVA range). UV irradiation within spectral range of 200-300 nm results in further photodestruction of thiamine and thiamine thiazolone and production of 2-methyl-4-amino-5aminomethyl-pyrimidine as the main photoproduct. The possibility to use thiamine disulfide derivatives as a promising class of anti-cataract drugs as well as drugs to decrease the toxic effect of ultraviolet radiation on human retina is discussed.

 

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The authors declare that there are no conflicts of interest present.