vestichИзвестия Национальной академии наук Беларуси. Серия химических наукProceedings of the National Academy of Sciences of Belarus, Chemical Series1561-83312524-2342The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1561-8331-2021-57-3-356-384vestich-672Research ArticleОБЗОРЫХимическая модификация различных соединений азотсодержащими гетероцикламиChemical modification of different compounds with nitrogen-containing heterocyclesАкишинаЕ. А.AkishinaE. A.

Акишина Екатерина Александровна – аспирант, мл. науч. сотрудник

ул. Сурганова, 13, 220072, Минск

Ekaterina A. Akishina – Postgraduate student, Junior Researcher

13, Surganov Str., 220072, Minsk 

che.semenovaea@mail.ruДикусарЕ. А.DikusarЕ. А.

Дикусар Евгений Анатольевич – канд. хим. наук, ст. науч. сотрудник

ул. Сурганова, 13, 220072, Минск

Evgenij A. Dikusar – Ph. D. (Chemistry), Senior Researcher

13, Surganov Str., 220072, Minsk 

dikusar@ifoch.bas-net.byИнститут физико-органической химии Национальной академии наук БеларусиInstitute of Physical Organic Chemistry of the National Academy of Sciences of Belarus202105092021573356384Copyright © Акишина Е.А., Дикусар Е.А., 20212021Акишина Е.А., Дикусар Е.А.Akishina E.A., Dikusar Е.А.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestichem.belnauka.by/jour/article/view/672

Соединения гетероциклического ряда имеют исключительно важное практическое значение, так как многие гетероциклы лежат в основе молекул ценнейших лекарственных веществ как природных (витамины, ферменты, алкалоиды и др.), так и синтетических биологически активных соединений. В работе в основном рассмотрены наиболее актуальные за последние 10 лет направления поиска лекарственных средств различного назначения путем модификации известных биоактивных природных, элементоорганических и каркасных соединений 1,2-азольным, оксазольным, оксадиазольным, тиазольным, триазольным, пиридиновым, пиримидиновым гетероциклами. Химическая модификация позволяет повысить водорастворимость соединений, что является важным при выборе путей наиболее рационального введения препарата в организм, уменьшить токсичность соответствующих веществ, увеличить широту терапевтического действия, а также придать веществам новые ценные лечебные свойства, что таким образом в значительной мере расширить их применение в медицине и сельском хозяйстве.

Heterocyclic compounds have an extremely important practical application, since many heterocycles are the basis of the most valuable medicinal substances, both natural (vitamins, enzymes, alkaloids, etc.) and synthetic biologically active compounds. The work mainly considers the most relevant directions for various purposes drugs search by modifying known bioactive natural, organoelement and framework compounds with 1,2-azole, oxazole, oxadiazole, thiazole, triazole, pyridine, pyrimidine heterocycles over the past 10 years. Chemical modification makes it possible to increase the water solubility of the compounds, which is important when choosing the pathways for the most rational drug introduction into the body, to reduce the toxicity of the corresponding substances, to increase the breadth of the therapeutic action, and also to give new valuable medicinal properties, thus significantly expanding their application in medicine and agriculture.

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The authors declare that there are no conflicts of interest present.