vestichИзвестия Национальной академии наук Беларуси. Серия химических наукProceedings of the National Academy of Sciences of Belarus, Chemical Series1561-83312524-2342The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1561-8331-2021-57-4-413-423vestich-685Research ArticleНЕОРГАНИЧЕСКАЯ ХИМИЯINORGANIC CHEMISTRYНанокомпозиты на основе апатитного трикальцийфосфата и аутофибринаNanocomposites based on apatitic tricalcium phosphate and autofibrinГлазовИ. Е.GlazovI. E.

Глазов Илья Евгеньевич – мл. науч. сотрудник

ул. Сурганова, 9/1, 220072, Минск, Республика Беларусь

Ilya E. Glazov – Junior Researcher

9/1, Surganova Str., 220072, Minsk, Republic of Belarus

che.glazov@mail.ruКрутькоВ. К.Krut’koV. K.

Крутько Валентина Константиновна – канд. хим. наук, доцент, зав. лаб.

ул. Сурганова, 9/1, 220072, Минск, Республика Беларусь

Valentina K. Krut’ko – Ph. D. (Chemistry), Associate Professor, Head of the Laboratory

9/1, Surganova Str., 220072, Minsk, Republic of Belarus

tsuber@igic.bas-net.byВласовР. А.VlasovR. A.

Власов Роман Алексеевич – ЛОР-врач

ул. Тростенецкая, 3, 220033, Минск, Республика Беларусь

Roman A. Vlasov – ENT specialist

3, Trostenetskaya Str., 220033, Minsk, Republic of Belarus

rvalekseevich@mail.ruМусскаяО. Н.MusskayaO. N.

Мусская Ольга Николаевна – канд. хим. наук, доцент, ст. науч. сотрудник

ул. Сурганова, 9/1, 220072, Минск, Республика Беларусь

Olga N. Musskaya – Ph. D. (Chemistry), Associate Professor, Senior Researcher

9/1, Surganova Str., 220072, Minsk, Republic of Belarus

musskaja@igic.bas-net.byКулакА. И.KulakA. I.

Кулак Анатолий Иосифович – член-корреспондент, д-р хим. наук, профессор, директор

ул. Сурганова, 9/1, 220072, Минск, Республика Беларусь

Anatoly I. Kulak – Corresponding Member of the National Academy of Sciences of Belarus, D. Sc. (Chemistry), Professor, Director

9/1, Surganova Str., 220072, Minsk, Republic of Belarus

kulak@igic.bas-net.byИнститут общей и неорганической химии Национальной академии наук БеларусиInstitute of General and Inorganic Chemistry of the National Academy of Sciences of BelarusМедицинский центр SANTE ООО «Медандровит»Medical-Center SANTE Ltd. “Medandrovit”202103122021574413423Copyright © Глазов И.Е., Крутько В.К., Власов Р.А., Мусская О.Н., Кулак А.И., 20212021Глазов И.Е., Крутько В.К., Власов Р.А., Мусская О.Н., Кулак А.И.Glazov I.E., Krut’ko V.K., Vlasov R.A., Musskaya O.N., Kulak A.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestichem.belnauka.by/jour/article/view/685

Методом осаждения при соотношении Ca/P 1,50, pH 9 и времени созревания от 30 мин до 7–14 сут получены нанокомпозиты в аутофибриновой матрице на основе апатитного трикальцийфосфата. Резорбируемость нанокомпозитов определялась составом кальцийфосфатов, которые при длительном созревании формировались в виде кальцийдефицитного гидроксиапатита при соотношении Ca/P 1,66, а в биополимерной матрице образовывались более растворимые формы кальцийфосфатов при соотношении Ca/P 1,53–1,59. Установлено, что фибриновый сгусток стабилизировал наряду с апатитным трикальцийфосфатом фазу аморфного фосфата кальция, которая после 800 °С превращалась в резорбируемый α-трикальцийфосфат. Цитратная плазма затрудняла превращение апатитного трикальцийфосфата в стехиометрический гидроксиапатит, что также способствовало формированию после 800 °С резорбируемого β-трикальцийфосфата. Совокупное влияние времени созревания и биополимерной матрицы определяло кальцийфосфатный состав, физико-химические и морфологические свойства нанокомпозитов и возможность управления их резорбируемостью.

Nanocomposites based on apatitic tricalcium phosphate in an autofibrin matrix were obtained by precipitation at a Ca/P ratio of 1.50, pH 9 and a maturation time from 30 min to 7–14 days. The resorbability of nanocomposites was determined by the composition of calcium phosphates, which, during long-term maturation, formed as the calcium-deficient hydroxyapatite with a Ca/P ratio of 1.66, whereas biopolymer matrix favored the formation of more soluble calcium phosphates with a Ca/P ratio of 1.53–1.59. It was found that the fibrin clot stabilized, along with apatitic tricalcium phosphate, the phase of amorphous calcium phosphate, which after 800 °C was transformed into resorbable α-tricalcium phosphate. Citrated plasma inhibited the conversion of apatitic tricalcium phosphate into stoichiometric hydroxyapatite, which also facilitated the formation of resorbable β-tricalcium phosphate after 800 °C. The combined effect of the maturation time and the biopolymer matrix determined the composition, physicochemical and morphological properties of nanocomposites and the possibililty to control its extent of resorption

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The authors declare that there are no conflicts of interest present.