vestichИзвестия Национальной академии наук Беларуси. Серия химических наукProceedings of the National Academy of Sciences of Belarus, Chemical Series1561-83312524-2342The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1561-8331-2021-57-4-488-501vestich-693Research ArticleОБЗОРЫСопряжение фосфолиполиза и монооксигеназного катализаInterconnection of phospholipolysis and monooxygenase catalysisЛитвинкоН. М.LitvinkoN. M.

Литвинко Наталья Михайловна – д-р хим. наук, доцент, зав. лаб.

ул. Купревича, 5/2, 220141, Минск, Республика Беларусь

Natalia M. Litvinko – D. Sc. (Chemistry), Associate Professor, Head of the laboratory

5/2, Kuprevich Str., 220141, Minsk, Republic of Belarus

al_h@mail.ruИнститут биоорганической химии Национальной академии наук БеларусиInstitute of Bioorganic Chemistry of the National Academy of Sciences of Be202103122021574488501Copyright © Литвинко Н.М., 20212021Литвинко Н.М.Litvinko N.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestichem.belnauka.by/jour/article/view/693

Представлен обзор основных экспериментальных результатов в области исследования взаимодействия in vivo и in vitro ферментных систем, ответственных за метаболизм арахидоновой кислоты. Обсуждаются возможные взаимосвязи на пути ее высвобождения из фосфолипидов (фосфолипазы А2) до превращения (цитохромы Р450) в важнейшие внутриклеточные мессенджеры передачи внешнего сигнала на внутренний «язык клетки».

A review of the main experimental results in the field of studying the interaction in vivo and in vitro of enzyme systems responsible for the metabolism of arachidonic acid is presented. Metabolic events from its release from phospholipids (phospholipase A2) to its transformation (cytochromes P450) into the most important intracellular messengers of external signal transmission to the internal “language of the cell” are discussed.

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The authors declare that there are no conflicts of interest present.