vestichИзвестия Национальной академии наук Беларуси. Серия химических наукProceedings of the National Academy of Sciences of Belarus, Chemical Series1561-83312524-2342The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1561-8331-2022-58-1-105-128vestich-711Research ArticleОБЗОРЫРоль пуриновых и пиримидиновых нуклеозидов и их производных в реакциях, катализируемых панкреатической фосфолипазой А2Role of purine and pyrimidine nucleosides and their derivatives in reactions catalyzed by pancreatic phospholipase A2ЛитвинкоН. М.LitvinkoN. M.

Литвинко Наталья Михайловна – доктор химических наук, доцент, заведующая лабораторией

ул. Купревича, 5/2, 220141, Минск

Litvinko Natalia M. – D. Sc. (Chemistry), Associate Professor, Head of the laboratory

5/2, Kuprevich Str., 220141, Minsk

al_h@mail.ruИнститут биоорганической химии Национальной академии наук БеларусиInstitute of Bioorganic Chemistry of the National Academy of Sciences of Belarus202211032022581105128Copyright © Литвинко Н.М., 20222022Литвинко Н.М.Litvinko N.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestichem.belnauka.by/jour/article/view/711

Представлен обзор результатов изучения взаимосвязи в системе «нуклеозиды–фосфолипаза А2», которая играет определяющую роль в метаболизме фосфолипидов и их производных – простагландинов, тромбоксанов и лейкотриенов как важнейших внутриклеточных мессенджеров. Рассмотрено влияние нуклеозидов на активность секреторной ФЛА2 и метаболизм липонуклеозидов, представляющих интерес в качестве специфических средств доставки нуклеозидных лекарств. Результаты этих исследований рассмотрены с точки зрения фармакологического потенциала липонуклеозидов как новых форм известных лекарственных препаратов.

A review of the results of studying the relationship in the system “nucleosides–phospholipase A2”, which plays a decisive role in the metabolism of phospholipids and their derivatives – prostaglandins, thromboxanes and leukotrienes as the most important intracellular messengers, is presented. The review considers the effect of nucleosides on the activity of secretory PLA2 and the metabolism of liponucleosides, which are of interest as specific delivery vehicles for nucleoside drugs. The results of these studies are considered from the point of view of the pharmacological potential of liponucleosides as new forms of known drugs.

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The authors declare that there are no conflicts of interest present.