vestichИзвестия Национальной академии наук Беларуси. Серия химических наукProceedings of the National Academy of Sciences of Belarus, Chemical Series1561-83312524-2342The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1561-8331-2023-59-3-202-210vestich-826Research ArticleОРГАНИЧЕСКАЯ ХИМИЯORGANIC CHEMISTRYСинтез 22- и 23-дегидроксибрассиностероидов стигмастанового рядаSynthesis of 22- and 23-dehydroxybrassinosteroids of the stigmastane seriesХрипачВ. А.KhripachV. A.

Хрипач Владимир Александрович – академик, д-р хим. наук, профессор, зав. лаб

ул. В. Ф. Купревича, 5/2, 220084, Минск

Khripach Vladimir A. – Academician, D. Sc. (Chemistry), Professor, Head of Laboratory

5/2, Kuprevich Str., 220084, Minsk

khripach@iboch.byЖабинскийВ. Н.ZhabinskiiV. N.

Жабинский Владимир Николаевич – член-корреспондент, д-р хим. наук, профессор, гл. науч. сотрудник

ул. В. Ф. Купревича, 5/2, 220084, Минск

Zhabinskii Vladimir N. – Corresponding Member of the National Academy of Sciences of Belarus, D. Sc. (Chemistry), Professor, Chief Researcher

5/2, Kuprevich Str., 220084, Minsk

vz@iboch.byСикоровЕ. В.SikorovE. V.

Сикоров Евгений Владимирович – лаборант

ул. В. Ф. Купревича, 5/2, 220084, Минск

Sikorov Evgeny V. – Laboratory Assistant

5/2, Kuprevich Str., 220084, Minsk

vz@iboch.byЛазаревС. И.LazarevS. I.

Лазарев Станислав Игоревич – мл. науч. сотрудник

ул. В. Ф. Купревича, 5/2, 220084, Минск

Lazarev Stanislav I. – Junior Researcher

5/2, Kuprevich Str., 220084, Minsk

stanislav-l@iboch.byИнститут биоорганической химии Национальной академии наук БеларусиInstitute of Bioorganic Chemistry of the National Academy of Sciences of Belarus202304092023593202210Copyright © Хрипач В.А., Жабинский В.Н., Сикоров Е.В., Лазарев С.И., 20232023Хрипач В.А., Жабинский В.Н., Сикоров Е.В., Лазарев С.И.Khripach V.A., Zhabinskii V.N., Sikorov E.V., Lazarev S.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestichem.belnauka.by/jour/article/view/826

Осуществлен синтез ранее неописанных 22- и 23-дезоксианалогов гомокастастерона, позволяющий получить целевые соединения без замены углеродного скелета боковой цепи. Ключевыми реакциями в их синтезе стали раскрытие эпоксидного цикла и радикальное дебромирование.

The synthesis of previously undescribed 22- and 23-deoxyanalogues of homocastasterone has been carried out, which makes it possible to obtain target compounds without replacing the carbon skeleton of the side chain. The key reactions in their synthesis were epoxy ring opening and radical debromination.

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The authors declare that there are no conflicts of interest present.