vestichИзвестия Национальной академии наук Беларуси. Серия химических наукProceedings of the National Academy of Sciences of Belarus, Chemical Series1561-83312524-2342The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1561-8331-2023-59-3-211-224vestich-827Research ArticleОРГАНИЧЕСКАЯ ХИМИЯORGANIC CHEMISTRYСинтез новых производных ремантадина и адамантан-1-карбоновой кислоты с 1,2-азольными фрагментамиSynthesis of novel rimantadine and adamantane-1-carboxylic acid derivatives with 1,2-azole fragmentsАкишинаЕ. А.AkishinaE. A.

Акишина Екатерина Александровна – науч. cотрудник

 

Akishina Ekaterina A. – Researcher

13, Surganov Str., 220072, Minsk

che.semenovaea@mail.ruДикусарЕ. А.DikusarЕ. А.

Дикусар Евгений Анатольевич – канд. хим. наук, ст. науч. сотрудник

ул. Сурганова, 13, 220072, Минск

Dikusar Evgenij A. – Ph. D. (Chemistry), Senior Researcher

13, Surganov Str., 220072, Minsk

dikusar@ifoch.bas-net.byКурманП. В.KurmanP. V.

Курман Петр Владимирович – канд. хим. наук, вед. науч. сотрудник

ул. Академика В. Ф. Купревича, 5/2, 220141

Kurman Peter V. – Ph. D. (Chemistry), Leading Researcher

5/2, Academician V. F. Kuprevich Str., 220141, Minsk

peter_kurman@tut.byПоткинВ. И.PotkinV. I.

Поткин Владимир Иванович – академик, д-р хим. наук, профессор, зав. лаб

ул. Сурганова, 13, 220072, Минск

Potkin Vladimir I. – Academician, D. Sc. (Chemistry), Professor, Head of the Laboratory

13, Surganov Str., 220072, Minsk

potkin@ifoch.bas-net.byИнститут физико-органической химии Национальной академии наук БеларусиInstitute of Physical Organic Chemistry of the National Academy of Sciences of BelarusИнститут биоорганической химии Национальной академии наук БеларусиInstitute of Bioorganic Chemistry of the National Academy of Sciences of Belarus202304092023593211224Copyright © Акишина Е.А., Дикусар Е.А., Курман П.В., Поткин В.И., 20232023Акишина Е.А., Дикусар Е.А., Курман П.В., Поткин В.И.Akishina E.A., Dikusar Е.А., Kurman P.V., Potkin V.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestichem.belnauka.by/jour/article/view/827

Конденсацией ремантадина с различными замещенными гидроксибензальдегидами, сложными и простыми эфирами на их основе, а также 1,2-азол-3-карбальдегидами с образованием азометинов и последующим восстановлением последних получены вариативные адамантановые производные. Дальнейшим ацилированием производных с активными амино- и гидроксигруппами получены соединения, содержащие в одной молекуле два 1,2-азольных фрагмента.

Various adamantane derivatives were obtained by the condensation of rimantadine with substituted hydroxy-benzaldehydes, esters and ethers based on them, as well as 1,2-azole-3-carbaldehydes, followed by reduction. Further acylation of derivatives with active amino and hydroxy groups yielded compounds containing two 1,2-azole fragments in one molecule.

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The authors declare that there are no conflicts of interest present.