vestichИзвестия Национальной академии наук Беларуси. Серия химических наукProceedings of the National Academy of Sciences of Belarus, Chemical Series1561-83312524-2342The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1561-8331-2025-61-1-30-40vestich-935Research ArticleФИЗИЧЕСКАЯ ХИМИЯPHYSICAL CHEMISTRYСтабилизированные фосфатом декстрана наночастицы селена для создания пролонгированной формы доксорубицинаDextran phosphate stabilized selenium nanoparticles for creating a prolonged-release form of doxorubicinОгородниковВ. Э.AharodnikauU E.

Огородников Владислав Эдуардович – аспирант, млад- ший научный сотрудник

ул. Ленинградская, 14, 220030, Минск

Aharodnikau Uladzislau E. – Postgraduate Student, Junior Researcher

14, Leningrad- skaya Str., 220030, Minsk

aharodnikau.u@gmail.comЕдчикА. В.YedchykA. V.

Едчик Александра Викторовна – техник

ул. Курчатова, 1, 220045, Минск

Yedchyk Aliaksandra V. – Technician

1, Kurchatov Str., 220045, Minsk

sasha.edchik@gmail.comПристромоваЮ. И.PristromovaYu. I.

Пристромова Юлия Игоревна – аспирант, младший научный сотрудник

ул. Ленинградская, 14, 220030, Минск

ул. Курчатова, 1, 220045, Минск

Pristromova Yulia I. – Postgraduate Student, Junior Researcher

14, Leningrad- skaya Str., 220030, Minsk

prystromyi@gmail.comБарановскаяА. В.BaranouskayaA. V.

Барановская Анастасия Викторовна – техник

ул. Курчатова, 1, 220045, Минск

Baranouskaya Anastasiya V. – Technician

1, Kurchatov Str., 220045, Minsk

nastybaranowskaya@gmail.comКорчевскаяА. Г.KarcheuskayaA. G.

Корчевская Ангелина Григорьевна – техник

ул. Курчатова, 1, 220045, Минск

Karcheuskaya Anhelina G. – Technician

1, Kurchatov Str., 220045, Minsk

angelina.korchevskaja@gmail.comЮнусовХ. Э.YunusovKh.

Юнусов Хайдар Эргашович – доктор технических наук, старший научный сотрудник

ул. А. Кадыри, д. 7 «б», 100128, Ташкент

Yunusov Khaydar – D. Sc. (Engineering), Senior Researcher

A. Kadiry Str., 7b, 100128, Tashkent

silver4727@yahoo.comСарымсаковА. А.SarymsakovA.

Сарымсаков Абдушкур Абдухалилович – доктор тех- нических наук, профессор

ул. А. Кадыри, д. 7 «б», 100128, Ташкент

Sarymsakov Abdushkur – D. Sc. (Engineering), Professor

A. Kadiry Str., 7b, 100128, Tashkent

polymer@academy.uzРашидоваС. Ш.RashidovaS.

Рашидова Сайёра Шарафовна – академик Академии наук Республики Узбекистан, директор

ул. А. Кадыри, д. 7 «б», 100128, Ташкент

Rashidova Saiora – Academician of The Academy of Sciences of the Republic of Uzbekistan, Director

A. Kadiry Str., 7b, 100128, Tashkent

polymer@academy.uzАлиновскаяВ. А.AlinovskayaV. А.

Алиновская Валентина Александровна – научный сотрудник

ул. Ленинградская, 14, 220030, Минск

Alinovskaya Valentina А. – Researcher

14, Leningradskaya Str., 220030, Minsk

БычковскийП. М.BychkovskyP. M.

Бычковский Павел Михайлович – кандидат химических наук, доцент, директор

ул. Курчатова, 1, 220045, Минск

Bychkovsky Pavel M. – Ph. D. (Chemistry), Associate Professor, Director

1, Kurchatov Str., 220045, Minsk

bychkovsky@tut.byЮркштовичТ. Л.YurkshtovichT. L.

Юркштович Татьяна Лукинична – кандидат химических наук, доцент, заведующий лаборатории

ул. Ленинградская, 14, 220030, Минск

Yurkshtovich Tatiana L. – Ph. D (Chemistry), Associate Professor, Head of the Laboratory

14, Leningradskaya Str., 220030, Minsk

Yurk@bsu.byНаучно-исследовательский институт физико-химических проблем Белорусского государственного университета; Унитарное предприятие «УНИТЕХПРОМ БГУ»; Белорусский государственный университетResearch Institute of Physical and Chemical Problems of the Belarusian State University; Unitary Enterprise “UNITEKHPROM BSU”; Belarusian State UniversityУнитарное предприятие «УНИТЕХПРОМ БГУ»; Белорусский государственный университетUnitary Enterprise “UNITEKHPROM BSU”; Belarusian State UniversityИнститут химии и физики полимеров Академии наук Республики УзбекистанInstitute of Chemistry and Physics of Polymers of the Academy of Sciences of the Republic of UzbekistanНаучно-исследовательский институт физико-химических проблем Белорусского государственного университетаResearch Institute of Physical and Chemical Problems of the Belarusian State UniversityНаучно-исследовательский институт физико-химических проблем Белорусского государственного университета; Унитарное предприятие «УНИТЕХПРОМ БГУ»Research Institute of Physical and Chemical Problems of the Belarusian State University; Unitary Enterprise “UNITEKHPROM BSU”2025270220256113040Copyright © Огородников В.Э., Едчик А.В., Пристромова Ю.И., Барановская А.В., Корчевская А.Г., Юнусов Х.Э., Сарымсаков А.А., Рашидова С.Ш., Алиновская В.А., Бычковский П.М., Юркштович Т.Л., 20252025Огородников В.Э., Едчик А.В., Пристромова Ю.И., Барановская А.В., Корчевская А.Г., Юнусов Х.Э., Сарымсаков А.А., Рашидова С.Ш., Алиновская В.А., Бычковский П.М., Юркштович Т.Л.Aharodnikau U.E., Yedchyk A.V., Pristromova Y.I., Baranouskaya A.V., Karcheuskaya A.G., Yunusov K., Sarymsakov A., Rashidova S., Alinovskaya V.А., Bychkovsky P.M., Yurkshtovich T.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestichem.belnauka.by/jour/article/view/935

Наночастицы селена были получены путем химического восстановления селенит-ионов аскорбиновой кислотой в растворах синтезированных фосфатов декстрана с различными степенями замещения по фосфорнокислым группам и среднемассовыми молекулярными массами, которые использовались в качестве стабилизатора. Установлено, что покрытые фосфатом декстрана наночастицы стабильны при хранении в течение трех суток. Изучена сорбция противоопухолевого вещества доксорубицина в интервале концентраций от 0,1 до 1 мг/мл. Показано значительное уменьшение скорости высвобождения доксорубицина из стабилизированных наночастиц, что может свидетельствовать о пролонгировании действия цитостатика. Наночастицы селена, покрытые водорастворимым фосфатом декстрана, могут быть использованы для создания лекарственных препаратов широкого спектра действия, в частности противоопухолевых и компенсирующих дефицит селена в организме.

Nanobiotechnology is an actively developing field of science, which finds application in cancer therapy, molecular diagnostics and molecular imaging. In this work, selenium nanoparticles were successfully obtained by chemical reduction of selenite ions with ascorbic acid in dextran phosphate (DP) solutions, which was used as a stabilizer. It has been found that dextran phosphate coated nanoparticles are stable during storage for 3 days. Sorption of the antitumor substance doxorubicin was studied in the concentration range from 0.1 mg/ml to 1 mg/ml. A significant prolongation of cytostatic release from stabilized nanoparticles was shown. Selenium nanoparticles coated with water-soluble DP can be used to create broad-spectrum drugs, in particular, antitumor drugs that compensate for selenium deficiency in the body.

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The authors declare that there are no conflicts of interest present.