vestichИзвестия Национальной академии наук Беларуси. Серия химических наукProceedings of the National Academy of Sciences of Belarus, Chemical Series1561-83312524-2342The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1561-8331-2025-61-3-196-205vestich-965Research ArticleНЕОРГАНИЧЕСКАЯ ХИМИЯINORGANIC CHEMISTRYГибридные композиты на основе карбонат-фосфатов кальция и фибрина, насыщеные антибиотикомHybrid composites based on calcium carbonate-phosphates and fibrin saturated with antibioticГлазовИ. Е.GlazovI. E.

Глазов Илья Евгеньевич – кандидат химических наук, старший научный сотрудник

ул. Сурганова, 9/1, 220072, Минск

Glazov Ilya E. – Ph. D. (Chemistry), Senior Researcher

9/1, Surganov Str., 220072, Minsk

che.glazov@mail.ruКрутькоВ. К.Krut’koV. K.

Крутько Валентина Константиновна – кандидат химических наук, доцент, заведующий лабораторией

ул. Сурганова, 9/1, 220072, Минск

Krut’ko Valentina K. – Ph. D. (Chemistry), Associate Professor, Head of the Laboratory

9/1, Surganov Str., 220072, Minsk

tsuber@igic.bas-net.byМусскаяО. Н.MusskayaO. N.

Мусская Ольга Николаевна – кандидат химических наук, доцент, ведущий научный сотрудник

ул. Сурганова, 9/1, 220072, Минск

Musskaya Olga N. – Ph. D. (Chemistry), Associate Professor, Leading Researcher

9/1, Surganov Str., 220072, Minsk

musskaja@igic.bas-net.byКрутькоЕ. Н.KrutskoE. N.

Крутько Евгений Николаевич – старший научный сотрудник

ул. Сурганова, 9/1, 220072, Минск

Krutsko Evgeny N. – Senior Researcher

9/1, Surganov Str., 220072, Minsk

ev_krutsko@igic.bas-net.byКулакА. И.KulakA. I.

Кулак Анатолий Иосифович – академик, доктор химических наук, профессор, директор

ул. Сурганова, 9/1, 220072, Минск

Kulak Anatoly I. – Academician, D. Sc. (Chemistry), Professor, Director

9/1, Surganov Str., 220072, Minsk

 

kulak@igic.bas-net.byИнститут общей и неорганической химии Национальной академии наук БеларусиInstitute of General and Inorganic Chemistry of the National Academy of Sciences of Belarus202529082025613196205Copyright © Глазов И.Е., Крутько В.К., Мусская О.Н., Крутько Е.Н., Кулак А.И., 20252025Глазов И.Е., Крутько В.К., Мусская О.Н., Крутько Е.Н., Кулак А.И.Glazov I.E., Krut’ko V.K., Musskaya O.N., Krutsko E.N., Kulak A.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestichem.belnauka.by/jour/article/view/965

Жидкофазным осаждением в присутствии цитратной плазмы (6–50 об.%) получены гибридные композиты на основе карбонат-фосфатов кальция и фибрина. Неорганическая составляющая композитов представлена аморфным карбонат-фосфатом кальция и аморфизированным карбонат-гидроксиапатитом (А-тип) с отношением Ca/P 1,71. После 15 суток выдерживания в модельном растворе SBF гибридные композиты обогащаются биомиметическим апатитом (до 8,8 мас.%) с сохранением отношения Ca/P 1,71. Фибриновые макромолекулы обеспечивают 2–частичное удаление CO32- -ионов из структуры гибридных композитов и повышенную апатитообразующую способность в модельном растворе SBF. Гибридные композиты поглощают до 92 % ципрофлоксацина из водных растворов; сорбционная емкость достигает 0,126 ммоль/г. В течение 10 суток выдерживания в физиологическом растворе композиты высвобождают до 89 % антибиотика; константа скорости высвобождения ципрофлоксацина композитами составляет 0,021 ммоль/(г ∙ ч0,25) против 0,051 ммоль/(г ∙ ч0,10) для карбонат-фосфатов кальция.

Hybrid composites based on calcium carbonate-phosphates and fibrin were obtained by wet precipitation in presence of citrated plasma (6–50 vol.%). Inorganic component of the composites represents amorphous calcium carbonatephosphates and  amorphized  carbonated  hydroxyapatite  (A-type)  with  a  Ca/P  ratio  of  1.71.  After  15  days  of  aging in the SBF model solution, the hybrid composites are enriched with biomimetic apatite (up to 8.8 wt.%) without changing  of Ca/P ratio of 1.71. Fibrin macromolecules provide partial removal of CO32–ions from the structure of hybrid composites and apatite-forming capacity in the model SBF solution. Hybrid composites absorb up to 92 % of ciprofloxacin from aqueous solutions; the sorption capacity reaches 0.126 mmol/g. During 10 days of soaking in physiological solution, the composites release up to 89 % of the antibiotic; rate constant of ciprofloxacin release for composites measures 0,021 mmol/(g ∙ h0.25) versus 0,051 mmol/(g ∙ h0.10) for calcium carbonate-phosphates

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The authors declare that there are no conflicts of interest present.