Peptide analogues of the epitopes of protein A interaction with IgG antibodies, their synthesis and investigation of target properties
Abstract
Using methods of theoretical conformational analysis, the Phe-Gln-Phe-Tyr-OMe tetrapeptide has been designed and synthesized. Amino acid fragments of this tetrapeptide are present in the active center of protein A, providing its binding with the Fc-fragment of human IgG antibodies. Activity of this tetrapeptide has been confirmed by studies of its binding affinity with Fc-fragment of human IgG antibodies.
About the Authors
A. V. Lapko
The Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
D. N. Kislaya
The Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
V. P. Golubovich
The Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
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