SYNTHESIS AND ANTIMYCOBACTERIAL PROPERTIES OF POLYFLUORINATED BENZALDOXIME AND PYRAZINECARBOXYLIC ACID ESTERS
Abstract
A series of polyfluorinated benzaldehyde oxime and pyrazinecarboxylic acid esters has been synthesized. Antimycobacterial properties of the synthesized compounds have been studied. It has been shown that several of the compounds are superior to currently used anti-TB drugs in their ability to slow the growth and development of mycobacteria
About the Authors
M. M. Kauhanka
Belarusian State Medical University
Russian Federation
Ph.D. (Chemistry), Associate Professor Department of Biological Chemistry
Russian Federation
Ph.D. (Chemistry), Associate Professor Department of Biological Chemistry
U. M. Kauhanka
The Belarusian State Technological University
Russian Federation
Ph.D. (Chemistry), Associate Professor Department of Analytical Chemistry
Russian Federation
Ph.D. (Chemistry), Associate Professor Department of Analytical Chemistry
I. M. Slabko
Belarusian State Medical University
Russian Federation
Senior Researcher
Russian Federation
Senior Researcher
References
1. Kovganko N.N., Kovganko V.N., Simonenko L.I. and Slabko I.N., ″Synthesis and antimycobacterial properties fluoroaryl-2-isoxazolines″, Vestsі Natsyyanal’nai akademіі navuk Belarusі. Seryya khіmіchnykh navuk [Proceedings of the National Academy of Sciences of Belarus. Chemistry Series], 2013, no. 1, pp. 73–77.
2. Kovganko N.N., Chernov Yu.G. and Kovganko V.N., ″The method of obtaining pyrazinamide″, Dostizheniya meditsinskoi nauki Belarusi: rets. nauch.-prakt. ezhegodnik [Advances in medical science in Belarus: a peer-reviewed scientific and practical Yearbook], RNMB, Minsk, BY, 2012, no. 17, pp. 111–112.
3. Kovganko N.N., Kovganko V.N., Simonenko L.I. and Slabko I.N., ″Use of technology laboratory synthesis of 3-aryl-3-ketoesters to obtain new fluorinated antimikobakteritsidov″, Dostizheniya meditsinskoi nauki Belarusi: rets. nauch.-prakt. ezhegodnik [Advances in medical science in Belarus: a peer-reviewed scientific and practical Yearbook], RNMB, Minsk, BY, 2012, no. 17, pp. 112–113.
4. Kovganko N.N., Kovganko V.N., Simonenko L.I. and Slabko I.N., ″Microbacterial activity of compounds containing 2-isoxazoline ring″, Novosti mediko-biologicheskikh nauk [News of Biomedical Sciences], 2013, vol. 7, no. 2, pp. 146–149.
5. Kovganko V.N., Kovganko N.N., Simonenko L.I., Slabko I.N., Zin’kova T.N. and Krech A.V., ″3-Aryl-3-ketoesters in the synthesis mikobakteritsidov″, Vestsі Natsyyanal’nai akademіі navuk Belarusі. Seryya khіmіchnykh navuk [Proceedings of the National Academy of Sciences of Belarus. Chemistry Series], 2013, no. 3, pp. 94–99.
6. Kovganko V.N., Kovganko N.N., Simonenko L.I., Slabko I.N., ″Substituted 3-aryl-3-ketoesters in the synthesis mikobakteritsidov″, Vestsі Natsyyanal’nai akademіі navuk Belarusі. Seryya khіmіchnykh navuk [Proceedings of the National Academy of Sciences of Belarus. Chemistry Series], 2015, no. 2, pp. 39–42.
7. Kovganko V.N., Kovganko N.N., Slabko I.N., ″Synthesis and antimycobacterial properties benzaldoxime fluorinated esters and pyrazinecarboxylic acid″, Vestsі Natsyyanal’nai akademіі navuk Belarusі. Seryya khіmіchnykh navuk [Proceedings of the National Academy of Sciences of Belarus. Chemistry Series], 2015, no. 3, pp. 70–73.
8. Janin Y.L. ″Antituberculosis drugs: Ten years of research″, Bioorganic and Medicinal Chemistry, 2007, vol. 15, no. 7, pp. 2479–2513.
9. Brown R. J., Annis G., Casalnuovo A., Chan D., Shapiro R., Marshall W. J., ″Synthesis and properties of axially-chiral N-(2,6-disubstituted)phenyl triazolones″, Tetrahedron, 2004, vol. 60, no. 20, pp. 4361–4375.
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