ASSOCIATES OF MAGNETITE, CERIA AND FE3O4/CEO2 NANOPARTICLE COMPOSITE WITH THE CHIMERIC AMIDES CONTAINING FRAGMENTS OF IMATINIB AND PEMETREXED
https://doi.org/10.29235/1561-8331-2018-54-1-7-15
Abstract
Associates of nanoparticles (NP) of magnetite, ceria and their composite – Fe3O4 / CeO2 – with new amides containing fragments of inhibitors оf protein kinase and histone deacetylases have been obtained. Inorganic particles were formed in the presence of amides, with the one-step preparation of nanocarrier and its functionalization. In the 40-fold dilute sol, the hydrodynamic diameter of the associates increases in the series (CeO2)C2 < (Fe3O4)C2 < (Fe3O4/CeO2)C2. In an aqueous solution of 0.05 N HCl, 155 mM NaCl, simulating gastric juice, the half-time of the agglomeration of magnetite and associate of (Fe3O4)C2 is 415 and 140 minutes, respectively.
About the Authors
A. N. Eryomin
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus
Belarus
Belarus
D. Sc. (Chemistry), Chief researcher
36, F. Skaryna Str., 220141, Minsk
Zh. V. Ihnatovich
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus
Belarus
Belarus
Ph. D. (Chemistry), Leading researcher
36, F. Skaryna Str., 220141, Minsk
Ch. A. Novik
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus
Belarus
Belarus
Junior researcher
36, F. Skaryna Str., 220141, Minsk
E. V. Logvinovich
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus
Belarus
Belarus
Junior researcher
36, F. Skaryna Str., 220141, Minsk
A. V. Abakshonok
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus
Belarus
Belarus
M. Sc. (Biological), Junior researcher
36, F. Skaryna Str., 220141, Minsk
E. V. Koroleva
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus
Belarus
Belarus
D. Sc. (Chemistry), Chief researcher
36, F. Skaryna Str., 220141, Minsk
V. E. Agabekov
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus
Belarus
Belarus
Academician, D. Sc. (Chemistry), Professor, Director of the Institute
36, F. Skaryna Str., 220141, Minsk
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