Protein-ligand interactions of CYP51 Candida glabrata and human CYP11В1 with 7-substituted 19-nortestosterones
https://doi.org/10.29235/1561-8331-2018-54-4-450-454
Abstract
The interaction of human monooxygenases and pathogenic fungi with previously obtained esters of isomeric 7-methyl-19-nor-testosterones and a number of heteroaromatic acids – derivatives of pyridine and pyrazine, was studied. Interaction with the active center of CYP11B1 derivatives of steroids of the androstane series containing methyl group at C7 and residues of heteroaromatic acids at C17β is shown.
About the Authors
T. V. Shkel
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus
Researcher
Belarus
Researcher
I. P. Grabovec
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus
Researcher
Belarus
Researcher
A. A. Gilep
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus
Ph. D. (Chemistry), Leading Researcher
Belarus
Ph. D. (Chemistry), Leading Researcher
T. S. Varaksa
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus
Junior Researcher
Belarus
Junior Researcher
N. V. Strushkevich
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus
Ph. D. (Chemistry), Leading Researcher
Belarus
Ph. D. (Chemistry), Leading Researcher
V. I. Dolgopalets
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus
Ph. D. (Chemistry), Leading Researcher
Belarus
Ph. D. (Chemistry), Leading Researcher
Yu. G. Charnou
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus
Ph. D. (Chemistry), Leading Researcher
Belarus
Ph. D. (Chemistry), Leading Researcher
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