Direct transformation of i-steroid methyl ethers in 6-ketones: the use in the synthesis of brassinosteroids
https://doi.org/10.29235/1561-8331-2019-55-2-175-181
Abstract
A one-step method for the transformation of 3α,5-cyclo-6β-methyl ethers of steroids into the corresponding 3α,5-cyclo-6-ketones under the action of methyl (trifluoromethyl) dioxirane has been developed. The possibilities of the method have been demonstrated by preparing 3-dehydrotesterone, the biosynthetic precursor of brassinolide.
Supporting agencies: The work has ben performed with the financial support of the Belarusian Republican Foundation for Fundamental Research (project no. Х18УКА-010).
About the Authors
A. L. Gurskii
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Alaksei L. Gurskii – Ph. D. (Chemistry), Leading researcher
5/2, Kuprevich Str., 220141, Minsk
V. N. Zhabinskii
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Vladimir N. Zhabinskii – Corresponding Member, D. Sc. (Chemistry), Associate Professor, Chief researcher
5/2, Kuprevich Str., 220141, Minsk
V. A. Khripach
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Vladimir A. Khripach – Academician, D. Sc. (Chemistry), Professor, Head of the Laboratory
5/2, Kuprevich Str., 220141, Minsk
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