Hibrid biomaterials based on hydroxyapatite and blood components
https://doi.org/10.29235/1561-8331-2019-55-3-299-308
Abstract
Hybrid biomaterials based on amorphous hydroxyapatite and blood components (fibrin, citrate plasma) were developed by chemical precipitation of hydroxyapatite in a biopolymer matrix (pH 11; Ca/P ratio 1.67) and by mixing 6–14 wt.% of hydroxyapatite gel (pH 7.0–7.2) with bipolymers. Chemically precipitated hydroxyapatite in biopolymer matrices is single phase or contains ticalcium phosphate impurity up to 30 %, mainly α-modification in fibrin matrix and β-modification in citrate plasma. The interaction of hydroxyapatite gel into the fibrin leads to significant amorphization of hydroxyapatite and an increase in its bioresorbability. Holding the composites with hydroxyapatite obtained by chemical precipitation in the Simulated Body Fluid model solution for 75 days leads to their partial resorption and simultaneous increase of biomimetic apatite, with its greater weight gain on composites with a fibrin. Hybrid biomaterials based on a fibrin obtained from the patient’s blood and hydroxyapatite gel showed positive result during implantation, allowing to form an adequate configuration of the defect, expanding the possibilities of ENT surgery.
About the Authors
V. K. Krut’ko
Institute of General and Inorganic Chemistry of National Academy of Sciences of Belarus
Belarus
Belarus
Valentina K. Krut’ko – Ph. D. (Chemistry), Associate professor, Leading researcher
9/1, Surganov Str., 220072, Minsk
R. A. Vlasov
Republican Hospital of Department of Finance and Logistics of the Ministry of Internal Affairs of Republic of Belarus
Belarus
Belarus
Roman A. Vlasov – ENT specialist
4, Zolotaya gorka Str, 220005, MinskO. N. Musskaya
Institute of General and Inorganic Chemistry of National Academy of Sciences of Belarus
Belarus
Belarus
Olga N. Musskaya – Ph. D. (Chemistry), Associate professor, Senior researcher
9/1, Surganov Str., 220072, MinskI. E. Glazov
Institute of General and Inorganic Chemistry of National Academy of Sciences of Belarus
Belarus
Belarus
Ilya E. Glazov – Junior researcher
9/1, Surganov Str., 220072, MinskA. I. Kulak
Institute of General and Inorganic Chemistry of National Academy of Sciences of Belarus
Belarus
Belarus
Anatoly I. Kulak – Corresponding Member of the National Academy of Sciences of Belarus, D. Sc. (Chemistry), Professor, Director
9/1, Surganov Str., 220072, Minsk
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