Synthesis of acylic derivatives of prolylleucylglycinamide
https://doi.org/10.29235/1561-8331-2019-55-4-429-435
Abstract
Tert-butyloxycarbonylprolylleucylglycinamide is obtained both by the interaction of tert-butyloxycarbonylprol ylleucylglycine ethyl ester with a methanolic ammonia solution and by the reaction of glycine amide with a mixed anhydride which was synthesized from tert-butyloxycarbonylprolylleucine and isobutylchloroformate. The removal of the tert-butyloxycarbonyl group by the action of formic acid or a dioxane solution of hydrogen chloride and treatment of the resulting salts with the corresponding base yielded a prolylleucylglycinamide, by the interaction of which with acetic, benzoic or 5-phenylisoxazole-3-carboxylic acids chlorides acyl derivatives of prolylleucylglycinamide are obtained.
About the Authors
V. A. Haidukevich
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Veranika A. Haidukevich – Junior Researcher.
13, Surganov Str., 220072, Minsk
S. K. Petkevich
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Sergey K. Petkevich – Ph. D. (Chemistry), Leading Researcher.
13, Surganov Str., 220072, Minsk
E. G. Karankevich
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Helen G. Karankevich – Ph. D. (Chemistry), Head of the Laboratory.
13, Surganov Str., 220072, Minsk
P. V. Kurman
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Peter V. Kurman – Ph. D. (Chemistry), Leading Researcher.
5/2, Academician V. F. Kuprevich Str., 220141, Minsk
Z. I. Kuvaeva
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Zoya I. Kuvaeva – D. Sc. (Chemistry), Professor, Head of the Department.
13, Surganov Str., 220072, Minsk
V. I. Potkin
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Vladimir I. Potkin – Сorresponding Member of the National Academy of Sciences of Belarus, D. Sc. (Chemistry), Professor, Head of the Department.
13, Surganov Str., 220072, Minsk
V. A. Knizhnikov
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Valeriy A. Knizhnikov – D. Sc. (Chemistry), Head of the Laboratory.
13, Surganov Str., 220072, Minsk
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