Synthesis of acyl derivatives of thiazolo[5.4-b]indole
https://doi.org/10.29235/1561-8331-2019-55-4-436-441
Abstract
2-Amino-4-acetylthiazolo[5,4-b]indole and its bromosubstituted analogue contain a free amino group and are initial compounds for chemical modification in order to obtain on their basis functional derivatives having high therapeutic activity. By the interaction of these 2-aminо-4-acetylthiazolo[5,4-b]indoles with succinic and maleic anhydrides, the corresponding imides and amides were obtained, which are of interest for use in order to create on their basis antihypoxic and actoprotective agents.
About the Authors
D. V. Lopatik
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Dina V. Lopatik – Ph. D. (Chemistry), Senior Researcher.
13, Surganov Str., 220072, Minsk
Z. I. Kuvaeva
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Zoya I. Kuvaeva – D. Sc. (Chemistry), Professor, Head of the Department.
13, Surganov Str., 220072, Minsk
O. M. Bondareva
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Olga M. Bondareva – Researcher.
13, Surganov Str., 220072, Minsk
V. E. Naidenov
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Vladimir E. Naidenov – Researcher.
13, Surganov Str., 220072, Minsk
L. Yu. Tychinskaya
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Lyudmila Yu. Tychinskaya – Researcher.
13, Surganov Str., 220072, Minsk
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