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Proceedings of the National Academy of Sciences of Belarus, Chemical Series

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Extraction of acid type penicillins by organic solvents

https://doi.org/10.29235/1561-8331-2020-56-3-284-292

Abstract

Extraction of six acid type penicillins (penicillin G, penicillin V, oxacillin, cloxacillin, nafcillin, dicloxacillin) from their water solutions by polar organic solvents (n-hexane, toluene, chloroform, isoamyl alcohol) was studied. Penicillins were quantified by high performance liquid chromatography-mass spectrometry. The penicillins distribution constants were calculated. А possibility of developing a fast, effective and inexpensive method for the determination of trace amounts of acid type penicillins in foodstuffs using extraction by chloroform was shown.

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ISSN 1561-8331 (Print)
ISSN 2524-2342 (Online)