Extraction of acid type penicillins by organic solvents
https://doi.org/10.29235/1561-8331-2020-56-3-284-292
Abstract
Extraction of six acid type penicillins (penicillin G, penicillin V, oxacillin, cloxacillin, nafcillin, dicloxacillin) from their water solutions by polar organic solvents (n-hexane, toluene, chloroform, isoamyl alcohol) was studied. Penicillins were quantified by high performance liquid chromatography-mass spectrometry. The penicillins distribution constants were calculated. А possibility of developing a fast, effective and inexpensive method for the determination of trace amounts of acid type penicillins in foodstuffs using extraction by chloroform was shown.
About the Authors
A. G. Polonevich
Scientific Practical Center of Hygiene
Belarus
Belarus
Anna G. Polonevich - doctoral student at the Department of Analytical Chemistry. BSU; Leading Chemist. SPCH.
14, Leningradskaya Str., 220030, Minsk ; 8, Akademicheskaya Str., 220012, Minsk
S. M. Leschev
Belarusian State University
Belarus
Belarus
Sergey M. Leschev - D. Sc. (Chemistry), Professor.
14, Leningradskaya Str., 220030, Minsk
A. I. Palianskikh
Scientific Practical Center of Hygiene
Belarus
Belarus
Alena I. Palianskikh - Ph. D. (Chemistry), Senior Researcher.
8, Akade-micheskaya Str., 220012, Minsk
L. L. Belyshava
Scientific Practical Center of Hygiene
Belarus
Belarus
Liudmila L. Belyshava - Head of the Laboratory.
8, Akademicheskaya Str., 220012, MinskReferences
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