Synthesis of leucine-based cyclic dipeptides
https://doi.org/10.29235/1561-8331-2020-56-3-3U-317
Abstract
3-benzyl-6-isobutylpiperazin-2,5-dione [cyclo(leucylphenylalanyl)], 3-isobutylpiperazin-2,5-dione [cyclo(-leucylglycyl)] and 3-(sec-butyl-)-6-isobutyl-piperazine-2,5-dione [cyclo(leucylisoleucine)] have been obtained by cyclization of methyl esters of tert-butyloxycarbonyl derivatives of dipeptides, for the synthesis of which both carbodiimide-promoted peptide bond formation and the mixed anhydride method were used.
About the Authors
V. A. Haidukevich
Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus,
Belarus
Belarus
Veranika A. Haidukevich - Researcher.
13, Surganov Str., 220072, Minsk
L. A. Popova
Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus,
Belarus
Belarus
Ludmila A. Popova - Senior Researcher.
13, Surganov Str., 220072, Minsk
P. V. Kurman
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus
Belarus
Belarus
Peter V. Kurman - Ph. D. (Chemistry), Leading Researcher.
5/2, Academician V. F. Kuprevich Str., 220141, Minsk
V. A. Knizhnikov
Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus,
Belarus
Belarus
Valeriy A. Knizhnikov - D. Sc. (Chemistry), Head of the Laboratory.
13, Surganov Str., 220072, Minsk
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