Peg derivatives for the synthesis of water-soluble cyanine dye Cy5
https://doi.org/10.29235/1561-8331-2021-57-1-41-47
Abstract
An effective method for the preparation of water-soluble cyanine dye Cy5 using the soluble polymers supported liquid-phase organic synthesis (LPOS) was proposed. Poly (ethylene glycol) methyl ether with a molecular weight of 2000 was used as a polymer substrate, which allowed us to simplify the characterization of products at intermediate stages of synthesis by NMR spectroscopy. This approach makes it easy to obtain the necessary cyanine dyes, which are widely used as fluorescent labels and are popular modifying reagents in biochemistry and medicine.
About the Authors
T. P. Seviarynchyk
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Tatsiana P. Seviarynchyk - Junior Researcher. Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus.
13, Surganov Str., 220072, Minsk.
Dz. V. Tsaulouski
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Dzmitry V. Tsaulouski - Researcher. Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus.
13, Surganov Str., 220072, Minsk.
O. L. Sharko
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Olga L. Sharko - Leading Researcher. Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus.
13, Surganov Str., 220072, Minsk.
V. V. Shmanai
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Vadim V. Shmanai - Ph. D. (Chemistry), Head of the Laboratory. Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus.
13, Surganov Str., 220072, Minsk.
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