Synthesis and study of the effect of arginine-vasopressin (6-9) analogue on the behavior of rats of different ages
https://doi.org/10.29235/1561-8331-2021-57-1-61-69
Abstract
The article presents the synthesis and results of the study of the effect of chronic neonatal administration by intranasal method of an analogue of the C-terminal fragment of arginine-vasopressin (AVP) - N-Ac-DMet-Pro-Arg-Gly-NH2 on the training and level of depression in white rats of three age groups. It is shown that the most significant effect of the analogue was manifested in the test for the development of conditional reaction of active avoidance. A favorable effect on the degree of depression of animals is also well expressed. According to the data obtained, we conclude that the action of the peptide is manifested only under the influence of a biologically significant stimulus.
About the Authors
K. V. Borodina
Institute of Bioorganic Chemistry of the National Academy of Science of Belarus
Belarus
Belarus
Kseniya V. Borodina - Junior Researcher, Institute of Bioorganic Chemistry of the National Academy of Science of Belarus.
5/2, Acad. V. F. Kuprevich Str., 220141, Minsk.
A. A. Stakhanova
M.V. Lomonosov Moscow State University, Biological Faculty
Russian Federation
Russian Federation
Anna A. Stakhanova - Graduate Student, M.V. Lomonosov Moscow State University.
1, p. 12, Leninskiye Gory, 119234, Moscow.
V. P. Martinovich
Institute of Bioorganic Chemistry of the National Academy of Science of Belarus
Belarus
Belarus
Vera P. Martinovich - Ph. D. (Chemistry), Leading Researcher, Institute of Bioorganic Chemistry of the National Academy of Science of Belarus.
5/2, Acad. V. F. Kuprevich Str., 220141, Minsk.
O. G. Voskresenskaya
M.V. Lomonosov Moscow State University, Biological Faculty
Russian Federation
Russian Federation
Olga G. Voskresenskaya - Ph. D. (Biology), Associate Professor, Senior Researcher, M.V. Lomonosov Moscow State University.
1, p. 12, Leninskiye Gory, 119234, Moscow.
V. P. Golubovich
Institute of Bioorganic Chemistry of the National Academy of Science of Belarus
Belarus
Belarus
Vladimir P. Golubovich - D. Sc. (Biology), Professor, Head of the Laboratory, Institute of Bioorganic Chemistry of the National Academy of Science of Belarus.
5/2, Acad. V. F. Kuprevich Str., 220141, Minsk.
A. A. Kamensky
M.V. Lomonosov Moscow State University, Biological Faculty
Russian Federation
Russian Federation
Andrey A. Kamensky - D. Sc. (Biology), Professor, Head of the Department, M.V. Lomonosov Moscow State University.
1, p. 12, Leninskiye Gory, 119234, Moscow.
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