Chemical modification of different compounds with nitrogen-containing heterocycles
https://doi.org/10.29235/1561-8331-2021-57-3-356-384
Abstract
Heterocyclic compounds have an extremely important practical application, since many heterocycles are the basis of the most valuable medicinal substances, both natural (vitamins, enzymes, alkaloids, etc.) and synthetic biologically active compounds. The work mainly considers the most relevant directions for various purposes drugs search by modifying known bioactive natural, organoelement and framework compounds with 1,2-azole, oxazole, oxadiazole, thiazole, triazole, pyridine, pyrimidine heterocycles over the past 10 years. Chemical modification makes it possible to increase the water solubility of the compounds, which is important when choosing the pathways for the most rational drug introduction into the body, to reduce the toxicity of the corresponding substances, to increase the breadth of the therapeutic action, and also to give new valuable medicinal properties, thus significantly expanding their application in medicine and agriculture.
Keywords
1,
2-azoles,
oxazole,
oxadiazole,
thiazole,
triazole,
pyridine,
pyrimidine,
curcumin,
vanillin,
chitosan,
steroids,
carborane,
ferrocene,
adamantane
About the Authors
E. A. Akishina
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Ekaterina A. Akishina – Postgraduate student, Junior Researcher
13, Surganov Str., 220072, Minsk
Е. А. Dikusar
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Evgenij A. Dikusar – Ph. D. (Chemistry), Senior Researcher
13, Surganov Str., 220072, Minsk
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