Hybrid composites based on calcium carbonate-phosphates and fibrin saturated with antibiotic

Hybrid composites based on calcium carbonate-phosphates and fibrin were obtained by wet precipitation in presence of citrated plasma (6–50 vol.%). Inorganic component of the composites represents amorphous calcium carbonatephosphates and  amorphized  carbonated  hydroxyapatite  (A-type)  with  a  Ca/P  ratio  of  1.71.  After  15  days  of  aging in the SBF model solution, the hybrid composites are enriched with biomimetic apatite (up to 8.8 wt.%) without changing  of Ca/P ratio of 1.71. Fibrin macromolecules provide partial removal of CO₃^2–ions from the structure of hybrid composites and apatite-forming capacity in the model SBF solution. Hybrid composites absorb up to 92 % of ciprofloxacin from aqueous solutions; the sorption capacity reaches 0.126 mmol/g. During 10 days of soaking in physiological solution, the composites release up to 89 % of the antibiotic; rate constant of ciprofloxacin release for composites measures 0,021 mmol/(g ∙ h^0.25) versus 0,051 mmol/(g ∙ h^0.10) for calcium carbonate-phosphates

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