Preview

Proceedings of the National Academy of Sciences of Belarus, Chemical Series

Advanced search

Conjugation of magnetite nanoparticles with oligonucleotides for magnetic delivery of oncolytic RNA

Abstract

The synthesis of magnetic nanoparticles conjugated with oligonucleotides has been described. The conjugates prepared were used for immobilization of the model oligonucleotide sequence imitating the oncolytic RNA strand fragment.

About the Authors

M. Yu. Tatulchenkov
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus


B. V. Ranishenka
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus


O. L. Sharko
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus


A. . Zayakina
Latvian Biomedical Research and Study Centre
Latvia


V. V. Shmanai
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus


References

1. Уразова, Л. Н. Онколитические вирусы в онкологии / Л. Н. Уразова, Т. И. Кузнецова // Сибир. онколог. журн. -2003. - № 4. - С. 28-35.

2. Kelly, E. History of Oncolytic Viruses: Genesis to Genetic Engineering / E. Kelly, S. J. Russell // Molecular therapy: the journal of the American Society of Gene Therapy. - 2007. - Vol. 15, № 4. - P. 651-659.

3. Segura, T. Materials for non-viral gene delivery / T. Segura, L. D. Shea // Annu. Rev. Mater. Res. - 2001. - Vol. 31. - P. 25-46.

4. Luo, D. Synthetic DNA delivery systems / D. Luo, W. M. Saltzman // Nature biotechnology. - 2000. - Vol. 18. -P. 33-37.

5. Михайлов, Г. А. Технология будущего: использование магнитных наночастиц в онкологии / Г. А. Михайлов, О. С. Васильева // Бюллетень СО РАМН. - 2008. - № 3. - C. 18-22.

6. Ito, A. Medical application of functionalized magnetic nanoparticles / A. Ito [et al.] // J. Biosci. Bioeng. - 2005. -Vol. 100, № 1. - Р. 1-11.

7. Motoyama, J. Size dependent heat generation of magnetite nanoparticles under AC magnetic field for cancer therapy / J. Motoyama [et al.] // BioMagnetic Research and Technology. - 2008. - Vol. 6, № 4.

8. Першина, А. Г. Взаимодействие магнитных наночастиц и молекул ДНК: создание нанобиогибридных структур и их использование / А. Г. Першина, А. Э. Сазонов, В. Д. Филимонов // Успехи химии. - 2014. - Т. 83, № 4. - С. 299-322.


Review

Views: 491


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1561-8331 (Print)
ISSN 2524-2342 (Online)