Дизайн, синтез и биологические свойства ингибиторов ВСR-ABL тирозинкиназы, применяемых для лечения хронического миелолейкоза

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Аннотация

Эффективность лечения хронического миелолейкоза существенно повысилась после введения в клиническую практику иматиниба - селективного ингибитора BCR-ABL тирозинкиназы. Описаны история разработки иматиниба, методы его синтеза и направления дальнейшей оптимизации структуры.

Об авторах

А. В. Фарина
Институт биоорганической химии НАН Беларуси
Беларусь


Е. Н. Калиниченко
Институт биоорганической химии НАН Беларуси
Беларусь


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