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SYNTHESIS OF HYDROPHILIC DERIVATIVES OF 11,11-D2-LINOLEIC ACID

Abstract

Previously it was shown that 11,11-D2-linoleic acid effectively quenches the processes of lipid peroxidation in vitro and in cell cultures due to the presence of reinforced C-D bonds in bis-allylic positions, which are most vulnerable to the radicals. Therefore, this compound serves as a promising candidate to treat mitochondrial and eye diseases. The present work deals with the synthesis of the hydrophilic derivatives of 11,11-D2-linoleic acid as prodrug forms with increased solubility in water and biological media and improved pharmacological properties. As modifying reagents, we chose biologically compatible natural compounds, mainly aminoacids, which were attached to 11,11-D2-linoleic acid via amide or ester bond. Among the synthesized compounds there are cationic, anionic and neutral derivatives, and their permeability in eyes will be further tested. 

About the Authors

M. A. Fomich
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus

Researcher

13, Surganov Str., 220072



O. L. Sharko
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus

Ph. D. (Chemistry), Senior Researcher

13, Surganov Str., 220072



V. V. Shmanai
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus

Ph. D. (Chemistry), Head of the Laboratory of Bioconjugate Chemistry

13, Surganov Str., 220072



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ISSN 1561-8331 (Print)
ISSN 2524-2342 (Online)