HETEROCYCLES DERIVATIVES OF METALLOCENES

The review article is devoted to the methodology of getting derivatives containing metallocene and heterocyclic fragments united in one molecule, which allows not only strengthening the specific action and the properties of the latter, but also obtaining compounds with radically new properties. Isoxazole is a part of many biologically active compounds, and its derivatives are used to treat diseases of the central nervous system, such as anti-tumor agents, analgesics, anesthetics, muscle relaxants, antibiotics. Purposefully synthesized isothiazole derivatives exhibit antiviral, anticancer, antibiotic activity, are effective immunosuppressive drugs, anti-inflammatory and antithrombotic agents. Derivatives of these azoles have a special place in agrochemicals as herbicides, pesticides, insecticides or fungicides. In turn, ferrocene compounds are of interest due to their wide range of chemical transformations and various ways of practical use in the art of electrochemistry, catalysis, and also in medicine and biology. Moreover, it is noted that the inclusion of the ferrocene moiety in an organic molecule often leads to completely new properties, including biological activity. This is due to the increase of penetration rate of material through the cell membranes due to the high lipophilicity of the ferrocene moiety, and therefore, the occurrence of abnormal metabolism ferrocene compound. Cymantrene derivatives applications are no less diverse; however, the use of biologically active compounds based on it is limited because of quite high toxicity of cymantrene fragment. Of great interest is the ability of the cymantrene structure to transmetallation with the formation of derivatives of other metallocenes. 

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