INFLUENCE OF COPOLYMER STRUCTURE AND LAYER-BY-LAYER SHELL ON AGGREGATIVE STABILITY OF (CHITOSAN-graft-POLYETHYLENE GLYCOL / POLYSTYRENE SULFONATE)n NANOCAPSULES
https://doi.org/10.29235/1561-8331-2018-54-2-135-145
Abstract
Nanocapsules consisted of magnetic core and polyelectrolyte shell on the basis of chitosan or its polyethylene glycol (PEG) grafted copolymers (CH) and polystyrene sulfonate (PSS) were obtained by layer-by-layer assembly. The influence of the number of CH/PSS bilayers in a shell, polymerization degree of CH, and the presence of grafted PEG chains on aggregative and sedimentation stability of the obtained nanocapsules in different media (water, 0.9 % NaCl solution, fetal bovine serum (FBS)) was discussed. It was shown that the diameter of PSS-terminated (CH/PSS)n nanocapsules in FBS does not change at 37 °С for 6–8 h. Adsorption of bovine serum albumin on the surface of the layer-by-layer nanocapsules stabilizes them in isotonic 0.9 % solution of NaCl and FBS. Co-introduction of copolymer and albumin in the shells improves generally the aggregative stability of nanocapsules in water and allows one to obtain stable nanocapsules with magnetic core for fewer adsorption cycles.
About the Authors
T. G. Shutava
Institute of Chemistry of New Materials, National Academy of Sciences of Belarus.
Belarus
Belarus
Tatsiana G. Shutava – Ph. D. (Сhemistry), Leading researcher.
36, F. Skaryna Str., 220141, Minsk.
K. S. Livanovich
Institute of Chemistry of New Materials, National Academy of Sciences of Belarus.
Belarus
Belarus
Kanstantsin S. Livanovich – Junior researcher.
36, F. Skaryna Str., 220141, Minsk.
V. V. Pankov
Belarusian State University.
Belarus
Belarus
Vladimir V. Pankov – D. Sc. (Сhemistry), Professor, Head of the Department.
14, Leningradskaya Str., 220030, Minsk.
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