LONG-LIVED RADIONUCLIDES IN THE PRODUCTION OF [18F]FLUOROCHOLINE FOR PET-DIAGNOSIS
https://doi.org/10.29235/1561-8331-2018-54-3-359-368
Abstract
In the present study the distribution of long-lived radionuclides between the drug product, recovered water [ 18O]H2 O and solid phase extraction cartridges was studied in [18F]fluorocholine production process. Isotopic composition for long-lived nuclides (half-lives = 10–312 days) was determined, the mechanisms of their formation and accumulation on cartridges are considered. It was shown that in the batches of pharmaceutical produced the content of long-lived nuclides is by 5 orders of magnitude lower than the limit value specified by the appropriate 07/2016:2793 European Pharmacopoeia article. The results obtained are of vital importance for optimization of the procedures for radioactive waste management in the production of [18F]fluorocholine using IBA Cyclone 18/9 HC cyclotron and, consequently, for minimization of radiation exposure of personnel.
About the Authors
P. V. Tylets
N. N. Alexandrov National Cancer Centre of Belarus
Belarus
Belarus
Pavel V. Tylets – Engineer for radiation and dosimetry monitoring
223040, a/g Lesnoi-2, Minsk District
O. V. Tugay
N. N. Alexandrov National Cancer Centre of Belarus, Belarusian State University
Belarus
Belarus
Оlga V. Tugay – Laboratory Technician
223040, a/g Lesnoi-2, Minsk District
Student
4, Nezavisimosty Ave., 220030, Minsk
V. O. Krot
N. N. Alexandrov National Cancer Centre of Belarus, Belarusian State University
Belarus
Belarus
Vadzim О. Krot – Laboratory Technician
223040, a/g Lesnoi-2, Minsk District
Student
4, Nezavisimosty Ave., 220030, Minsk
A. A. Ivaniykovich
Belarusian State Institute for Metrology
Belarus
Belarus
Аlexander А. Ivaniykovich – Leading Engineer
93, Starovilensky trakt, 220053, Minsk
S. A. Soroka
Belarusian State Institute for Metrology
Belarus
Belarus
Sergey A. Soroka – Head of Production-Research Department for the measurement of ionizing radiation
93, Starovilensky trakt, 220053, Minsk
D. I. Brinkevich
N. N. Alexandrov National Cancer Centre of Belarus, Belarusian State University
Belarus
Belarus
Dmitrii I. Brinkevich – Ph. D. (Physics and Mathematics), Engineer for the registration and storage of nuclear and radioactive materials
223040, a/g Lesnoi-2, Minsk District
Leading Researcher
4, Nezavisimosty Ave., 220030, Minsk
S. D. Brinkevich
N. N. Alexandrov National Cancer Centre of Belarus, Belarusian State University
Belarus
Belarus
Svyatoslav D. Brinkevich – Ph. D. (Chemistry), Head of cyclotron-radiochemistry laboratory
223040, a/g Lesnoi-2, Minsk District
Associate Professor
4, Nezavisimosty Ave., 220030, Minsk
O. A. Baranovski
N. N. Alexandrov National Cancer Centre of Belarus
Belarus
Belarus
Aleg А. Baranovski – Head of PET/CT diagnostics laboratory
223040, a/g Lesnoi-2, Minsk District
G. V. Chizh
N. N. Alexandrov National Cancer Centre of Belarus
Belarus
Belarus
Georgi V. Chizh – Ph. D. (Medicine), Head of Positronemission Tomography Department
223040, a/g Lesnoi-2, Minsk District
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