Synthesis of chimeric amides of 2-arilaminopyrimidine series
https://doi.org/10.29235/1561-8331-2020-56-2-38-166-180
Abstract
Methodological approaches to the synthesis of 2-arylpyrimidine amides with predicted antitumor activity using the design of chimeric molecules by combining pharmacophore fragments of known antitumor drugs are considered. The results of the synthesis of chimeric amides containing, along with the 2-amino-pyrimidine fragment, fragments of other nitrogen and oxygen-containing heterocycles (piperazine, morpholine, isoxazole, etc.), aromatic cycles (benzene, methylnitroaniline, phenylenediamine) and functional (methyl-, amino-, carboxy-, etc.) groups in different positions of the molecule, are presented.
About the Author
Zh. V. Ignatovich
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus
Belarus
Belarus
Zhanna V. Ignatovich – Ph. D. (Chemistry), Head of the Laboratory
36, F. Skorina Str., 220141, Minsk
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