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Proceedings of the National Academy of Sciences of Belarus, Chemical Series

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Synthesis of chalcone-based pyrimidine derivatives and their antimicrobial activity

https://doi.org/10.29235/1561-8331-2021-57-4-431-437

Abstract

A series of substituted chalcones and pyrimidine derivatives on their base was synthesized. Obtained compounds were tested for antimicrobial activity and ability to increase activity of known antimicrobial substances. Pyrimidine products shown good activity against Staphylococcus aureus and Candida tropicalis. These compounds also could increase activity of modified polyguanidines against Staphylococcus aureus.

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ISSN 1561-8331 (Print)
ISSN 2524-2342 (Online)