Synthesis of chalcone-based pyrimidine derivatives and their antimicrobial activity
https://doi.org/10.29235/1561-8331-2021-57-4-431-437
Abstract
A series of substituted chalcones and pyrimidine derivatives on their base was synthesized. Obtained compounds were tested for antimicrobial activity and ability to increase activity of known antimicrobial substances. Pyrimidine products shown good activity against Staphylococcus aureus and Candida tropicalis. These compounds also could increase activity of modified polyguanidines against Staphylococcus aureus.
About the Authors
D. S. Martsinkevich
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus
Belarus
Belarus
Denis S. Martsinkevich – Junior Researcher
36, F. Skaryna str., 220141, Minsk, Republic of Belarus
K. F. Chernyavskaya
Belarusian State Technological University
Belarus
Belarus
Katerina F. Chernyavskaya – Assistant of Biotechnology Department
13 a, Sverdlova str., 220006, Minsk, Republic of Belarus
V. A. Tarasevich
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus
Belarus
Belarus
Vladimir A. Tarasevich – D. Sc. (Chemistry), Professor, Chief Researcher
36, F. Skaryna str., 220141, Minsk, Republic of Belarus
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