Arginine nicotinates: preparation and properties
https://doi.org/10.29235/1561-8331-2026-62-2-95-106
Abstract
New derivatives of arginine and nicotinic acid with essential elements zinc and magnesium were obtained and characterized. A method for producing arginine nicotinate with a purity of 99.80 % and a yield of 88.00 % has been developed, and its IR and NMR spectroscopic characteristics have been obtained. A method for obtaining zinc and magnesium derivatives of arginine nicotinate has been developed. Based on NMR and IR spectra, the structure of the obtained compounds was confirmed. The composition of the obtained samples was determined using elemental analysis and complexometric titration. The content of the target component for zinc arginine nicotinate was 92.64 ± 0.32 %, and for magnesium arginine nicotinate – 85.12 ± 0.81 %.
About the Authors
E. G. Karankevich
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Karankevich Elena G. – Ph. D. (Chemistry), Head of the Laboratory.
13, Surganov Str., 220072, Minsk
M. M. Markovich
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Markovich Marina M. – Researcher.
13, Surganov Str., 220072, Minsk
V. E. Naidenov
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Naidenov Vladimir E. – Researcher.
13, Surganov Str., 220072, Minsk
Z. I. Kuvaeva
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Kuvaeva Zoya I. – Dr. Sci. (Chemistry), Professor, Head of the Department.
13, Surganov Str., 220072, Minsk
References
1. Tousoulis D., Antoniades C., Tentolouris C., Goumas G., Stefanadis C., Toutouzas P. L-arginine in cardiovascular disease: dream or reality? Vascular Medicine, 2002, vol. 7, no. 3, pp. 203–211. https://doi.org/10.1191/1358863x02vm434ra
2. Lopatik D. V., Kuvaeva Z. I., Bondareva O. M. Synthesis and cardioprotective efficacy of arginine succinate. Vestsi Natsyyanal’nai akademii navuk Belarusi. Seryya khimichnyh navuk = Proceedings of the National Academy of Science of Belarus. Chemical series, 2020, vol. 56, no. 2, pp. 181–186 (in Russian). https://doi.org/10.29235/1561-8331-2020-56-2-181-186
3. Berezin, A. E. Therapeutic potential of L-arginine in cardiovascular diseases. Ukrainian Medical Journal, 2019, vol. 1, pp. 2–5 (in Russian). https://doi.org/10.32471/umj.1680-3051.130.141109
4. Stepanov Yu. M., Kononov I. N., Zhurbina A. I., Filippova A. Yu. Arginine in medical practice. Journal of the Academy of Medical Sciences of Ukraine, 2004, vol. 10, no. 1, pp. 340–352 (in Russian).
5. Sipahi S., Gungor O., Gunduz M. Cilci M., Demirci M. C., Tamer A. The effect of oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine and glutamine on wound healing: a retrospective analysis of diabetic haemodialysis patients. BMC Nephrol, 2013, vol. 14, art. 8. https://doi.org/10.1186/1471-2369-14-8
6. Churakaev M. V., Balabekova M. K. The effect of arginine in the complex therapy of eczema on the clinical and immunological parameters of patients. Modern problems of science and education, 2016, no. 2. Available at: https:// science-education.ru/ru/article/view?id=24297 (accessed 07 October 2022) (in Russian).
7. Savust’yanenko A. V. L-Arginine accelerates wound healing: new mechanisms and clinical research data. Travma, 2018, vol. 19, no. 1, pp. 27–33 (in Russian). https://doi.org/10.22141/1608–1706.1.19.2018.127299
8. Aim-High Investigators. Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy. New England Journal of Medicine, 2011, vol. 365, pp. 2255–2267. https://doi.org/10.1056/nejmoa1107579
9. Truhacheva E. P., Ezhov M. V. The importance of nicotinic acid in modern cardiology. Rational Pharmacotherapy in Cardiology, 2011, vol. 7, no. 3, pp. 365–370 (in Russian).
10. Vincerskaya G. A., Marakah M. Y. A. N. On the use of nicotinic acid preparation as an inducer of immune–dependent fibrinolysis in patients with acute and chronic forms of foot mycosis. Crimea Journal of Experimental and Clinical Medicine, 2015, vol. 5, no. 1, pp.10–13 (in Russian).
11. Krisilova E. V., Eliseeva T. V., Selemenev V. F. Hydration of homogeneous and heterogeneous cation exchange membranes in hydrogen and arginine forms. Sorbtsionnye i Khromatograficheskie Protsessy = Sorption and Chromatography Processes, 2009, vol. 9, no. 6, pp. 835–843 (in Russian).
12. Plastun I. L., Zaharov A. A., Naumov A. A. Spectral manifestations of the mechanisms of intermolecular interaction of maleimide–modified polyelectrolyte capsules used in targeted therapy. Optika i spektroskopiya= Optics and Spectroscopy, 2023, vol. 131, no. 6, pp. 717–725 (in Russian). https://doi.org/10.21883/os.2023.06.55904.117-23
13. Sunatkari A. L., Talwatkar S. S., Tamgadge Y. S., Muley G. G. Synthesis, Characterization and Optical Properties of L-Arginine Stabilized Gold Nanocolloids. Nanoscience and Nanotechnology, 2015, vol. 5, no. 2, pp. 30–35. https://doi. org/10.5923/j.nn.20150502.02
14. Vasilyeva N. Yu., Levdansky A. V., Kazachenko A. S., Skvortsova G. P., Kuznetsov B. N., Djakovitch L., Pinel C. Synthesis of sulfated arabinogalactane derivatives with histidine and arginine. Journal of Siberian Federal University. Chemistry, 2016, vol. 3, no. 9, pp. 318–325 (in Russian). https://doi.org/10.17516/1998-2836-2016-9-3-318-325
15. Bellamy L. Infrared spectra of complex molecules. Moscow, Izd. inostr. lit., 1963. 590 p. (in Russian).
16. Kaziev G. Z., Stepnova A. F., Nguyen V. B., Khrustalev V. N., Dorovatovsky P. V., Quenones S. H. Synthesis and characterization of pyridine-3-carboxylic acid hexamolybdochromate (С6H5NO2)2[H3O]4[CrMo6O18(OH)6]4Н2О]. Butlerovskie soobshcheniya = Butlerov communications, 2019, vol. 59, no. 7, pp. 50–55 (in Russian).
17. Skal’naya M. G., Baranova O. V. Essential chemical elements: guidelines. Orenburg, OGU, 2012, 36 p. (in Russian).
18. Baryshnikova G. A., Chorbinskaya S. A., Stepanova I. I., Blohina O. E. Deficiency of potassium and magnesium, their role in the development of cardiovascular diseases and the possibility of correction. Consilium Medicum, 2019, vol. 21, no. 1, pp. 67–73 (in Russian). https://doi.org/10.26442/20751753.2019.1.190240
19. Gosudarstvennaya farmakopeya RF XIII izd. 2015 g. Kompleksonometricheskoe titrovanie [State Pharmacopoeia of the Russian Federation, XIII edition. Complexometric titration]. (OFS.1.2.3.0015.15) (in Russian).
20. Tarasevich B. N. IR spectra of the main classes of organic compounds. Reference materials. Moscow, MGU Publ., 2012. – 55 p. (in Russian).
21. Larkin P. J. Infrared and raman spectroscopy: principles and spectral interpretation. Elsevier, 2011. 230 p.
22. Levy G., Nelson G. Carbon-13 Nuclear Magnetic Resonance Guidelines for Organic Chemists. Moscow, Mir Publ., 1975. 296 p. (in Russian).
Review
Views:
657
JATS XML
Email this article 