Design, synthesis and biological properties of BCR-ABL tyrosine kinase inhibitors used for chronic myelogenous leucemia treatment
Abstract
Imatinib, a selective BCR-ABL tyrosine kinase inhibitor has significantly improved efficacy of chronic myelogenous leukemia treatment. This review focuses on discovery and development of imatinib, methods of its synthesis and further structure optimization opportunities.
About the Authors
A. V. Farina
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
E. N. Kalinichenko
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
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