TRIFLUOROACETYL AMINO-PROTECTIVE GROUP IN SYNTHESIS OF L-ALANYLL-GLUTAMIC ACID AND L-α,γ-GLUTAMYL-BIS(L-ALANINE)
Abstract
N-Trifluoroacetyl-L-alanyl-L-glutamic acid dimethyl ester and N-trifluoroacetyl-L-α,γ-glutamyl-bis(methoxy-L-alanine) were obtained by condensation of N-trifluoroacetyl-L-alanine with L-glutamic acid dimethyl ester and N-trifluoroacetyl-L-glutamic acid with L-alanine methyl ester, respectively. Removal of protecting groups by sodium hydroxide in the compounds obtained and subsequent acidification of the reaction mixtures led to the formation of L-alanylL-glutamic acid and L-α,γ-glutamyl-bis(L-alanine). N-Trifluoroacetyl-L-alanine and N-trifluoroacetyl-L-glutamic acid were obtained from L-alanine and L-glutamic acid sodium salts using ethyl trifluoroacetate as an acetylating agent.
About the Authors
L. A. Popova
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
Senior Researcher
13, Surganov Str., 220072
Z. P. Zubreichuk
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
Senior Researcher
13, Surganov Str., 220072
V. A. Knizhnikov
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
D. Sc. (Chemistry), Head of the Laboratory
13, Surganov Str., 220072
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