СИНТЕЗ НОВЫХ 6-N-ЗАМЕЩЕННЫХ ПУРИНОВЫХ НУКЛЕОЗИДОВ
https://doi.org/10.29235/1561-8331-2018-54-3-305-313
Анатацыя
Осуществлен синтез новых производных пуриновых нуклеозидов, содержащих в 6-положении гетерооснования остатки N,N-диэтилэтилендиамина или N-(2-аминоэтил)пирролидина. Разработанные условия проведения реакции аминирования ряда 6-Cl-производных О-ацетилированных пуриновых нуклеозидов и сопутствующих реакций дезацилирования ОН-групп углеводного фрагмента под действием N-этилдиизопропиламина или N-(2-аминоэтил)пирролидина позволили получить деблокированные 6-N-замещенные нуклеозиды в одну стадию с хорошими выходами.
Аб аўтарах
Т. Кулак
Институт биоорганической химии Национальной академии наук Беларуси
Беларусь
Беларусь
Д. Янковская
Институт биоорганической химии Национальной академии наук Беларуси
Беларусь
Беларусь
А. Коноплич
Институт биоорганической химии Национальной академии наук Беларуси
Беларусь
Беларусь
Т. Буравская
Институт биоорганической химии Национальной академии наук Беларуси, НПЦ «ХимФармСинтез»
Беларусь
Беларусь
Е. Калиниченко
Институт биоорганической химии Национальной академии наук Беларуси
Беларусь
Беларусь
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