SYNTHESIS OF NEW 6-N-SUBSTITUTED PURINE NUCLEOSIDES
https://doi.org/10.29235/1561-8331-2018-54-3-305-313
Abstract
New derivatives of purine nucleosides containing the residues of N,N-diethylethylenediamine or N-(2-aminoethyl)pyrrolidine in 6-position of heterobase have been synthesized. The one-step preparation of 6-N-substituted nucleosides was performed in good yields by the amination of 6-Cl-derivatives of O-acetylated purine nucleosides and concomitant deacylation of OH-groups of a carbohydrate moiety with N,N-diethylethylenediamine or N-(2-aminoethyl)pyrrolidine.
About the Authors
T. I. Kulak
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Tamara I. Kulak – Ph. D. (Chemistry), Leading Researcher
5/2, Acad. V.F. Kuprevich Str., 220141, Minsk
D. V. Yankovskaya
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Darya V. Yankovskaya – Engineer-Chemist, Research and Experimental Production “ChemPharmSynthesis”
5/2, Acad. V.F. Kuprevich Str., 220141, Minsk
A. V. Konoplich
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Alena V. Konoplich – Chemist-Pharmacist, Research and Experimental Production “ChemPharmSynthesis”
5/2, Acad. V.F. Kuprevich Str., 220141, Minsk
T. N. Buravskaya
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Tatyana N. Buravskaya – Ph. D. (Chemistry), Senior Researcher, Research and Experimental Production “ChemPharmSynthesis”
5/2, Acad. V.F. Kuprevich Str., 220141, Minsk
E. N. Kalinichenko
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Elena N. Kalinichenko – Corresponding Member, D. Sc. (Chemistry), Deputy Director
5/2, Acad. V.F. Kuprevich Str., 220141, Minsk
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