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LONG-LIVED RADIONUCLIDES IN THE PRODUCTION OF [18F]FLUOROCHOLINE FOR PET-DIAGNOSIS

https://doi.org/10.29235/1561-8331-2018-54-3-359-368

Abstract

In the present study the distribution of long-lived radionuclides between the drug product, recovered water [ 18O]H2 O and solid phase extraction cartridges was studied in [18F]fluorocholine production process. Isotopic composition for long-lived nuclides (half-lives = 10–312 days) was determined, the mechanisms of their formation and accumulation on cartridges are considered. It was shown that in the batches of pharmaceutical produced the content of long-lived nuclides is by 5 orders of magnitude lower than the limit value specified by the appropriate 07/2016:2793 European Pharmacopoeia article. The results obtained are of vital importance for optimization of the procedures for radioactive waste management in the production of [18F]fluorocholine using IBA Cyclone 18/9 HC cyclotron and, consequently, for minimization of radiation exposure of personnel.

About the Authors

P. V. Tylets
N. N. Alexandrov National Cancer Centre of Belarus
Belarus

Pavel V. Tylets – Engineer for radiation and dosimetry monitoring

223040, a/g Lesnoi-2, Minsk District



O. V. Tugay
N. N. Alexandrov National Cancer Centre of Belarus, Belarusian State University
Belarus

Оlga V. Tugay – Laboratory Technician

223040, a/g Lesnoi-2, Minsk District

Student

4, Nezavisimosty Ave., 220030, Minsk



V. O. Krot
N. N. Alexandrov National Cancer Centre of Belarus, Belarusian State University
Belarus

Vadzim О. Krot – Laboratory Technician

223040, a/g Lesnoi-2, Minsk District

Student

4, Nezavisimosty Ave., 220030, Minsk



A. A. Ivaniykovich
Belarusian State Institute for Metrology
Belarus

Аlexander А. Ivaniykovich – Leading Engineer

93, Starovilensky trakt, 220053, Minsk



S. A. Soroka
Belarusian State Institute for Metrology
Belarus

Sergey A. Soroka – Head of Production-Research Department for the measurement of ionizing radiation

93, Starovilensky trakt, 220053, Minsk



D. I. Brinkevich
N. N. Alexandrov National Cancer Centre of Belarus, Belarusian State University
Belarus

Dmitrii I. Brinkevich – Ph. D. (Physics and Mathematics), Engineer for the registration and storage of nuclear and radioactive materials

223040, a/g Lesnoi-2, Minsk District

Leading Researcher

4, Nezavisimosty Ave., 220030, Minsk



S. D. Brinkevich
N. N. Alexandrov National Cancer Centre of Belarus, Belarusian State University
Belarus

Svyatoslav D. Brinkevich – Ph. D. (Chemistry), Head of cyclotron-radiochemistry laboratory

223040, a/g Lesnoi-2, Minsk District

Associate Professor

4, Nezavisimosty Ave., 220030, Minsk



O. A. Baranovski
N. N. Alexandrov National Cancer Centre of Belarus
Belarus

Aleg А. Baranovski – Head of PET/CT diagnostics laboratory

223040, a/g Lesnoi-2, Minsk District



G. V. Chizh
N. N. Alexandrov National Cancer Centre of Belarus
Belarus

Georgi V. Chizh – Ph. D. (Medicine), Head of Positronemission Tomography Department

223040, a/g Lesnoi-2, Minsk District



References

1. Peller P., Subramaniam R., Guermazi A. (ed) PET-CT and PET-MRI in Oncology: A Practical Guide. Medical Radiology. Berlin. London, Springer Publ., 2012. 437 p. https://doi.org/10.1007/978-3-642-01139-9

2. Silveira M. B., Ferreira S. M. Z. M. D., Nascimento L. T. C., Costa F. M., Mendes B. M., Ferreira A. V., Malamut C., Silva J. B., Mamede M. Preclinical acute toxicity, biodistribution, pharmacokineticks, radiation dosimetry and microPET imaging studies of [18F]fluorocholine in mice. Applied Radiation and Isotopes. 2016, vol. 116, no 1, pp. 92–101 https://doi. org/10.1016/j.apradiso.2016.07.021

3. Brinkevich S. D., Sukonko O. G., Chizh G. V., Naumovich A. S. Positron-emission tomography. Part 1: method description. Production of radiopharmaceuticals. Medico-biologicheskie problemy zhiznedeyatel’nosti = Medical and biological problems of life activity, 2013, vol. 10, no 2, pp. 129–137 (in Russian).

4. Brinkevich D. I., Brinkevich S. D., Baranovsky O. A., Chizh G. V., Ivanyukovich А. А. Long-lived radionuclides in production of 2-[18F]fluorodeoxyglucose. Meditsinskaya fizika = Medical physics, 2018, no 1, pp. 1–6 (in Russian).

5. Kryza D., Tadino V., Filannino M. A., Villeret G., Lemoucheux L. Fully automated [18F]fluorocholine synthesis in the TracerLab MXFDG Coincidence synthesizer. Nuclear Medicine and Biology. 2008, vol. 35, no 2, pp. 255–260. https://doi. org/10.1016/j.nucmedbio.2007.11.008

6. Sanitary norms and specifications № 142 from 31.12.2015. Requirements to security of radiation safety of staff and population at radioactive waste management. Available at: http://www.svetlcge.by/wp-content/uploads/2015/01/ постановление-мз-рб-от-31.12.2015-№-142.pdf.

7. Firestone R. B., Shirley V. S. Table of radioactive isotopes. New York, John Wiley and Sons Publ., 1988. 1056 p.

8. Bowden L., Vintro L. L., Mitchell P. I., O’Donnell P. G., Seymour A. M., Duffy G. J. Radionuclide impurities in proton-irradiated [18O]H2 O for the production of 18F− : Activities and distribution in the [18F]FDG synthesis process. Applied Radiation and Isotope, 2009, vol. 67, no 2, pp. 248–255. https://doi.org/10.1016/j.apradiso.2008.10.015

9. Gillies J. M., Najim N., Zweit J. Analysis of metal radioisotope impurities generated in [18O]H2 O during the cyclotron production of fluorine-18. Applied Radiation and Isotopes, 2006, vol. 64, no 4, pp. 431–434. https://doi.org/10.1016/j.apradiso.2005.08.008

10. Ito S., Sakane H., Deji S., Saze T., Nishizawa K. Radioactive byproducts in [18O]H2 O used to produce 18F for [18F]FDG synthesis. Applied Radiation and Isotopes, 2006, vol. 64, no 3, pp. 298–305. https://doi.org/10.1016/j.apradiso.2005.10.001

11. Guarino P., Rizzo S., Tomarchio E., Greco D. Gamma-ray spectrometric characterization of waste activated target components in a PET cyclotron. 18th International Conference on Cyclotrons and Their Applications. 1–5 Oct 2007. Giardini Naxos, Messina, Italy, pp. 295–297.

12. Schueller M. J., Alexoff D. L., Schlyer D. J. Separating long-lived metal ions from 18F during H2 18O recovery. Nuclear Instruments and Methods in Physics Research B, 2007, vol. 261, pp. 795–799. https://doi.org/10.1016/j.nimb.2007.04.193

13. Ulrici L., Brugger M., Otto Th., Roesler S. Radionuclide characterization studies of radioactive waste produced at high-energy accelerators. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2006, vol. 562, no 2, pp. 596–600. https://doi.org/10.1016/j.nima.2006.02.043

14. Aygun M., Cesur A., Dogru M., Boztosun I., Dapo H., Kanarya M., Kuluozturk M. F., Bal S. S., Karatepe S. Using a clinical linac to determine the energy levels of 92mNb via the photonuclear reaction. Applied Radiation and Isotopes, 2016, vol. 115, no 1, pp. 97–99. https://doi.org/10.1016/j.apradiso.2016.06.007


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ISSN 1561-8331 (Print)
ISSN 2524-2342 (Online)