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Proceedings of the National Academy of Sciences of Belarus, Chemical Series

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The synthesis of chalcones containing isoxazole moiety

https://doi.org/10.29235/1561-8331-2019-55-1-53-57

Abstract

The synthesis of new chalcones with potential biological activity, including the reactions of chloromethylation, N-alkylation, Claisen-Schmidt condensation, was carried out. The compounds obtained contain an isoxazole moiety in their structure.

About the Authors

D. P. Boiko
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus
Belarus

Daria P. Boiko – Junior Researcher.

36; F. Skaryna Str., 220141, Minsk.



D. S. Martsinkevich
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus
Belarus

Denis S. Martsinkevich – trainee of Junior Researcher.

36; F. Skaryna Str., 220141, Minsk.



V. A. Tarasevich
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus
Belarus

Vladimir  A.  Tarasevich  –  D.  Sc.  (Chemistry),  Head of the Laboratory of Polymer Bioactive Substances.

36; F. Skaryna Str., 220141, Minsk.



References

1. Dao T. T., Chi Y. S., Kim J., Kim H.P., Kim S., Park H. Synthesis and PGE2 inhibitor y activity of 5,7-dihydroxyflavones and their o-methylated flavone analogs. Archives of Pharmacal Research, 2003, vol. 26, no. 5, pp. 345–350. https://doi.org/10.1007/bf02976690

2. Aitmambetov A., Menlimuratova Z. Interaction of synthetic analogues of nat ural chalcones and f lavones with guanidine. Russian Journal of Bioorganic Chemistry, 2003, vol. 29, no. 2, pp. 175–176. https://doi.org/10.1023/a:1023216600889

3. Fu X., Feng J., Dong Z., Lin L., Liu X., Feng X. Enantioselective synthesis of 2-substituted-1,5-benzodiazepines through Domino reaction of o-phenylenediamine and chalcone derivatives. European Journal of Organic Chemistry, 2011, no. 27, pp. 5233–5236. https://doi.org/10.1002/ejoc.201100938

4. Prashar H., Chawla A., Sharma A.K., Kharb R. Chalcone as a versatile moiety for diverse pharmacological activities. International Journal of Pharmaceutical Sciences and Research, 2012, vol. 3, no. 7, pp. 1913–1927.

5. Fuson R. C., McKeever C.H. Chloromethylation of aromatic compounds. Organic reactions. JohnWiley&Sons, Inc., 2011, pp. 63–90. https://doi.org/10.1002/0471264180.or001.03

6. Chinh L. V., Hung T. N., Nga N. T., Hang T. T. N., Mai T. T. N., Tarasevich V.A. Synthesis and antimicrobial activity of chalcones containing benzotriazolylmethyl and imidazolylmethyl substituents. Russian Journal of Organic Chemistry, 2014, vol. 50, no. 12, pp. 1767–1774. https://doi.org/10.1134/s1070428014120094

7. Cheng M. A., Li R. S., Kenyon G. A solid phase synthesis of chalcones by Claisen-Schmidt condensations. Chinese Chemistry Letters, 2000, vol. 11, no. 10, pp. 851–854.


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ISSN 1561-8331 (Print)
ISSN 2524-2342 (Online)