Synthesis of novel rimantadine and adamantane-1-carboxylic acid derivatives with 1,2-azole fragments
https://doi.org/10.29235/1561-8331-2023-59-3-211-224
Abstract
Various adamantane derivatives were obtained by the condensation of rimantadine with substituted hydroxy-benzaldehydes, esters and ethers based on them, as well as 1,2-azole-3-carbaldehydes, followed by reduction. Further acylation of derivatives with active amino and hydroxy groups yielded compounds containing two 1,2-azole fragments in one molecule.
Keywords
rimantadine,
5-arylisoxazoles,
4,5-dichloroisothiazole,
ethers and esters,
amides,
azomethines,
amines,
acylation
Supporting agencies: This work has been performed with a financial support of Belarusian Republican Foundation for Fundamental Research (grant no. Х21M-050).
About the Authors
E. A. Akishina
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Akishina Ekaterina A. – Researcher
13, Surganov Str., 220072, Minsk
Е. А. Dikusar
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Dikusar Evgenij A. – Ph. D. (Chemistry), Senior Researcher
13, Surganov Str., 220072, Minsk
P. V. Kurman
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Kurman Peter V. – Ph. D. (Chemistry), Leading Researcher
5/2, Academician V. F. Kuprevich Str., 220141, Minsk
V. I. Potkin
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Potkin Vladimir I. – Academician, D. Sc. (Chemistry), Professor, Head of the Laboratory
13, Surganov Str., 220072, Minsk
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