The effect of stabilizers on properties of calcium alginate nanoparticles
Abstract
In the process of 210-240 nm calcium alginate nanoparticles (AlgNP) non-emulsion synthesis from solutions with the 50-250-fold weight excess of stabilizers, polyethelyneglycol (PEG 1500) and Tween 80, as compared to polysaccharide, their molecules are incorporated in the forming gel in minimal concenrations (less than 64 ± 14 and 19 ± 9 mg/g on dry weight basis, accordingly). Their presence in solution decreases AlgNP size and stabilizes colloids. PEG 1500 macromolecules embedded into AlgNP slightly decrease gel polarity, while in AlgNP obtained with Tween 80, the local pockets formed by surfactant hydrophobic tails have been found.
About the Authors
O. A. Masalova
Институт химии новых материалов НАН Беларуси
Belarus
Belarus
T. G. Shutava
Институт химии новых материалов НАН Беларуси
Belarus
Belarus
References
1. Knop K., hoogenboom R., Fischer D., Schubert U. S. // Angew. Chem. Int. Ed. 2010. Vol. 49, N 36. P. 6288-6308.
2. Sikarra D., Shukla V., Kharia A. A., Chatterjee D. P. // JMPAS. 2012. Vol. 1, N 1. Р. 1-22.
3. Сафонова Т. Я., Петрий О. А., Паписов И. М. // Вестн. МГУ. Сер. 2. Химия. 2001. Т. 42, № 5. С. 345-348.
4. Wu W., he Q., Jiang C. // Nanoscale Res. Lett. 2008. Vol. 3, N 11. P. 397-415.
5. Allen T. M., Cullis P. R. // Science. 2004. Vol. 303, N 5665. С. 1818-1822.
6. Sun W., Xie Ch., Wang H., Hu Y. // Biomaterials. 2004. Vol. 25, N 15. С. 3065-3071.
7. Chen J., Spear S. K., Huddleston J. G., Rogers R. D. // Green. Chem. 2005. Vol. 7, N 1. P. 64-82.
8. Tartaj P., del Puerto Morales M., Veintemillas-Verdaguer S., Gonzalez-Carreno T., Serna C. J. // J. Phys. D: Appl. Phys.2003. Vol. 36, N 13. P. R182-R197.
9. Ali M. E., Lamprecht A. // Int. J. Pharm. 2013. Vol. 456, N 1. P. 135-142.
10. Masalova O., Kulikouskaya V., Shutava T., Agabekov V. // Physics Procedia. 2013. Vol. 40. P. 69-75.
11. Nag A., Mitra G., Chash P. // Analytical Biochemistry. 1996. Vol. 237, N 2. P. 224-231.
12. Cheng T.-L., Chuang K.-H., Chen B.-M., Roffler S. R. // Bioconjugate Chem. 2012. Vol. 23, N 5. P. 881-899.
13. Gilani G., Moghadam M., Zakerhamidi M. S. // Dyes and Pigments. 2012. Vol. 92, N 3. P. 1052-1057.
14. Greenspan P. , Fowler S. D. // J. Lipid Research. 1985. Vol. 26, N 7. P. 781-789.
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